The reduced expression of e-cadherin, alpha-catenin and gamma-catenin but not beta-catenin in human lung cancer.

  • Authors:
    • H Toyoyama
    • K Nuruki
    • H Ogawa
    • M Yanagi
    • H Matsumoto
    • H Nishijima
    • T Shimotakahara
    • T Aikou
    • M Ozawa
  • View Affiliations

  • Published online on: January 1, 1999     https://doi.org/10.3892/or.6.1.81
  • Pages: 81-86
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Abstract

Cadherins are Ca2+-dependent cell-cell adhesion molecules, and are involved in the formation and maintenance of the histo-architecture. Using a combination of biochemical and immunohistochemical methods, we analyzed the expression of cadherin-catenin complexes in 37 non-small cell lung carcinomas. In 19 cases, decreased expression of E-cadherin protein was observed. In 12 of them, decreased expression of alpha-catenin protein was also observed. Thus, decreased expression of alpha-catenin was apparently preceded by decreased expression of E-cadherin. In no cases was decreased expression of beta-catenin observed. In the 12 cases in which mRNA expression was analyzed by Northern blot analysis, decreased expression of mRNAs for E-cadherin and alpha-catenin was observed in 11 and 9 cases, respectively. In cases with reduced E-cadherin and alpha-catenin expression, immunohistochemistry revealed two types of staining pattern for the proteins. In the first type, almost all the cells in a tumor were stained weakly (homogeneous pattern). In the second type, different percentages of cells were stained strongly, the rest being almost negative for the staining (heterogeneous pattern).

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Jan-Feb 1999
Volume 6 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Toyoyama H, Nuruki K, Ogawa H, Yanagi M, Matsumoto H, Nishijima H, Shimotakahara T, Aikou T and Ozawa M: The reduced expression of e-cadherin, alpha-catenin and gamma-catenin but not beta-catenin in human lung cancer.. Oncol Rep 6: 81-86, 1999
APA
Toyoyama, H., Nuruki, K., Ogawa, H., Yanagi, M., Matsumoto, H., Nishijima, H. ... Ozawa, M. (1999). The reduced expression of e-cadherin, alpha-catenin and gamma-catenin but not beta-catenin in human lung cancer.. Oncology Reports, 6, 81-86. https://doi.org/10.3892/or.6.1.81
MLA
Toyoyama, H., Nuruki, K., Ogawa, H., Yanagi, M., Matsumoto, H., Nishijima, H., Shimotakahara, T., Aikou, T., Ozawa, M."The reduced expression of e-cadherin, alpha-catenin and gamma-catenin but not beta-catenin in human lung cancer.". Oncology Reports 6.1 (1999): 81-86.
Chicago
Toyoyama, H., Nuruki, K., Ogawa, H., Yanagi, M., Matsumoto, H., Nishijima, H., Shimotakahara, T., Aikou, T., Ozawa, M."The reduced expression of e-cadherin, alpha-catenin and gamma-catenin but not beta-catenin in human lung cancer.". Oncology Reports 6, no. 1 (1999): 81-86. https://doi.org/10.3892/or.6.1.81