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Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.

  • Authors:
    • A Goto
    • K Shomori
    • T Ohkumo
    • F Tanaka
    • K Sato
    • H Ito

  • View Affiliations

  • Published online on: March 1, 1999     https://doi.org/10.3892/or.6.2.335
  • Pages: 335-344
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Abstract

We examined the role of the p53 gene in hyperthermia-induced apoptosis using three human gastric carcinoma cell lines, MKN-28 (carrying mutated type p53 gene), MKN-74 (wild-type), and KATO-III (complete deletion). The results indicate that i) long-term hyperthermia causes necrosis, and short-term treatment induces apoptosis in a gradual time dependent fashion, ii) hyperthermia-triggered apoptosis can occur both in a p53 gene-dependent and -independent manner, and iii) up-regulation of Hsp70 might enhance the function of wild-type p53 protein in hyperthermia-induced apoptosis.

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Mar-Apr 1999
Volume 6 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Goto A, Shomori K, Ohkumo T, Tanaka F, Sato K and Ito H: Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.. Oncol Rep 6: 335-344, 1999
APA
Goto, A., Shomori, K., Ohkumo, T., Tanaka, F., Sato, K., & Ito, H. (1999). Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.. Oncology Reports, 6, 335-344. https://doi.org/10.3892/or.6.2.335
MLA
Goto, A., Shomori, K., Ohkumo, T., Tanaka, F., Sato, K., Ito, H."Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.". Oncology Reports 6.2 (1999): 335-344.
Chicago
Goto, A., Shomori, K., Ohkumo, T., Tanaka, F., Sato, K., Ito, H."Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.". Oncology Reports 6, no. 2 (1999): 335-344. https://doi.org/10.3892/or.6.2.335