Prognostic factors in colorectal cancer.

Cerottini,J P; Caplin,S; Pampallona,S; Givel,J C

doi:10.3892/or.6.2.409

Mar-Apr 1999 Volume 6 Issue 2

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Medicine International

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Mar-Apr 1999 Volume 6 Issue 2

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Article

Prognostic factors in colorectal cancer.

Authors:
- J P Cerottini
- S Caplin
- S Pampallona
- J C Givel
View Affiliations / Copyright

Affiliations: Service de Chirurgie, BH 15, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne-CHUV, Switzerland.
Pages: 409-423
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Published online on: March 1, 1999

https://doi.org/10.3892/or.6.2.409
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Abstract

Prognosis of patients after colorectal cancer resection is predominantly influenced by the extent of local tumour growth and the presence or absence of nodal or distant metastasis. However, many factors have been used to generate numerous classification systems, leading to some debate and confusion. The effects on survival of 7 clinical and pathological parameters were reviewed in 801 consecutive patients operated upon with locally curative intent for colorectal cancer over a ten-year period. Age less than 50 or more than 70 years, poor cellular differentiation, high mucous secretion by tumour cells and Dukes' staging were the parameters significantly correlated to poor overall survival (p<0.001 for each). The Cox's regression analysis identified the same parameters as independent prognostic factors. The value of age as a prognostic factor remains debatable, but the other three parameters must be considered when evaluating prognosis after curative surgery for colorectal cancer and when considering adjuvant therapy.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prognostic factors in colorectal cancer.

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Abstract

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