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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May-Jun 1999 Volume 6 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-Jun 1999 Volume 6 Issue 3

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Article

Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells.

  • Authors:
    • S M Planchon
    • S M Wuerzberger-Davis
    • J J Pink
    • K A Robertson
    • W G Bornmann
    • D A Boothman

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Laboratory of Molecular Stress Responses, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Pages: 485-577
    |
    Published online on: May 1, 1999
       https://doi.org/10.3892/or.6.3.485
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Abstract

We previously demonstrated that beta-lapachone (beta-lap) killed cancer cells solely by apoptosis. Beta-Lap induced apoptosis in HL-60 cells in a dose-dependent manner as measured by flow cytometry and DNA ladder formation. Cell cycle changes, such as accumulations in S and G2-phases, were not observed. Apoptosis was accompanied by activation of caspase 3 and concomitant cleavage of poly(ADP-ribose) polymerase (PARP) to an 89 kDa polypeptide. PARP cleavage was blocked by zDEVD-fmk or zVAD-fmk, caspase-specific cleavage site inhibitors. Retrovirally introduced bcl-2 prevented beta-lap-mediated caspase 3 activation and PARP cleavage and increased the viability of Bcl-2-expressing HL-60 cells compared to cells with vector alone. Various beta-lap-related analogs (e.g., dunnione and naphthoquinone derivatives) induced equivalent apoptosis in HL-60 cells, but no compound was more effective than beta-lap. These data provide further evidence that the primary mode of cell killing by beta-lap is by the initiation and execution of apoptosis in human cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Planchon S, Wuerzberger-Davis S, Pink J, Robertson K, Bornmann W and Boothman D: Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells.. Oncol Rep 6: 485-577, 1999.
APA
Planchon, S., Wuerzberger-Davis, S., Pink, J., Robertson, K., Bornmann, W., & Boothman, D. (1999). Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells.. Oncology Reports, 6, 485-577. https://doi.org/10.3892/or.6.3.485
MLA
Planchon, S., Wuerzberger-Davis, S., Pink, J., Robertson, K., Bornmann, W., Boothman, D."Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells.". Oncology Reports 6.3 (1999): 485-577.
Chicago
Planchon, S., Wuerzberger-Davis, S., Pink, J., Robertson, K., Bornmann, W., Boothman, D."Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells.". Oncology Reports 6, no. 3 (1999): 485-577. https://doi.org/10.3892/or.6.3.485
Copy and paste a formatted citation
x
Spandidos Publications style
Planchon S, Wuerzberger-Davis S, Pink J, Robertson K, Bornmann W and Boothman D: Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells.. Oncol Rep 6: 485-577, 1999.
APA
Planchon, S., Wuerzberger-Davis, S., Pink, J., Robertson, K., Bornmann, W., & Boothman, D. (1999). Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells.. Oncology Reports, 6, 485-577. https://doi.org/10.3892/or.6.3.485
MLA
Planchon, S., Wuerzberger-Davis, S., Pink, J., Robertson, K., Bornmann, W., Boothman, D."Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells.". Oncology Reports 6.3 (1999): 485-577.
Chicago
Planchon, S., Wuerzberger-Davis, S., Pink, J., Robertson, K., Bornmann, W., Boothman, D."Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells.". Oncology Reports 6, no. 3 (1999): 485-577. https://doi.org/10.3892/or.6.3.485
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