Inhibition of liver metastasis of colon cancer by in vivo administration of anti-vascular endothelial growth factor antibody.

  • Authors:
    • K Okamoto
    • Y Oshika
    • Y Fukushima
    • M Yoshimura
    • Y Ohnishi
    • T Tokunaga
    • T Hashimoto
    • H Hatanaka
    • Y Tomii
    • Y Yoshida
    • S Miura
    • T Tsuchida
    • H Kijima
    • H Yamazaki
    • M Nakamura
    • Y Ueyama
  • View Affiliations

  • Published online on: May 1, 1999     https://doi.org/10.3892/or.6.3.553
  • Pages: 553-559
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Abstract

Cancer metastasis via blood vessels is a complicated process involving a number of stages. Vascularization in the cancer stroma is essential for the metastatic process. Vascular endothelial growth factor (VEGF) is an angiogenic factor, and has important roles in tumor progression or metastasis. In this study, we developed a polycolonal antibody to VEGF and examined whether the anti-VEGF antibody could inhibit the metastasis of human xenografts expressing VEGF in nude mice. The xenograft Col-23-JCK expressing VEGF formed metastatic lesions in the liver and/or pancreas when inoculated via the portal vein (splenic vein) into nude mice. The anti-VEGF polyclonal antibody inhibited metastasis to the liver and/or pancreas (4.75+/- 3.62, anti-VEGF-treated vs. 9.73 +/- 8.24, w/o anti-VEGF treatment; Student's t-test, p=0.035). Vascularity in the metastatic lesions was also decreased by anti-VEGF treatment. These results suggest that anti-VEGF antibody administration may be therapeutically useful for prevention of colon cancer metastasis.

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May-Jun 1999
Volume 6 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Okamoto K, Oshika Y, Fukushima Y, Yoshimura M, Ohnishi Y, Tokunaga T, Hashimoto T, Hatanaka H, Tomii Y, Yoshida Y, Yoshida Y, et al: Inhibition of liver metastasis of colon cancer by in vivo administration of anti-vascular endothelial growth factor antibody.. Oncol Rep 6: 553-559, 1999.
APA
Okamoto, K., Oshika, Y., Fukushima, Y., Yoshimura, M., Ohnishi, Y., Tokunaga, T. ... Ueyama, Y. (1999). Inhibition of liver metastasis of colon cancer by in vivo administration of anti-vascular endothelial growth factor antibody.. Oncology Reports, 6, 553-559. https://doi.org/10.3892/or.6.3.553
MLA
Okamoto, K., Oshika, Y., Fukushima, Y., Yoshimura, M., Ohnishi, Y., Tokunaga, T., Hashimoto, T., Hatanaka, H., Tomii, Y., Yoshida, Y., Miura, S., Tsuchida, T., Kijima, H., Yamazaki, H., Nakamura, M., Ueyama, Y."Inhibition of liver metastasis of colon cancer by in vivo administration of anti-vascular endothelial growth factor antibody.". Oncology Reports 6.3 (1999): 553-559.
Chicago
Okamoto, K., Oshika, Y., Fukushima, Y., Yoshimura, M., Ohnishi, Y., Tokunaga, T., Hashimoto, T., Hatanaka, H., Tomii, Y., Yoshida, Y., Miura, S., Tsuchida, T., Kijima, H., Yamazaki, H., Nakamura, M., Ueyama, Y."Inhibition of liver metastasis of colon cancer by in vivo administration of anti-vascular endothelial growth factor antibody.". Oncology Reports 6, no. 3 (1999): 553-559. https://doi.org/10.3892/or.6.3.553