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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May-Jun 1999 Volume 6 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-Jun 1999 Volume 6 Issue 3

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Article

Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission.

  • Authors:
    • S Tamura
    • Y Takemoto
    • S Takami
    • M Kinoshita
    • Y Kumano
    • H Aono
    • M Mori
    • E Kakishita

  • View Affiliations / Copyright

    Affiliations: Second Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
  • Pages: 683-688
    |
    Published online on: May 1, 1999
       https://doi.org/10.3892/or.6.3.683
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Abstract

We analyzed the efficacy of all-trans retinoic acid (ATRA) as an early treatment for four acute promyelocytic leukemia (APL) patients in remission who were PML/RARalpha-positive by reverse transcription-polymerase chain reaction or fluorescence in situ hybridization. ATRA 45 mg/m2 was administered orally. All became negative for PML/RARalpha transcripts after 3 to 6 months of ATRA treatment. However, the PML/RARalpha transcripts subsequently reverted to positive in three cases. Although retreatment with ATRA failed to prevent hematological relapse in two patients, one case remains in hematological remission. No serious side effects were encountered during ATRA treatment. These findings suggest that early treatment of ATRA for PML/RARalpha-positive APL patients in remission may have a therapeutic benefit and prolong the duration of hematological remission without chemotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Tamura S, Takemoto Y, Takami S, Kinoshita M, Kumano Y, Aono H, Mori M and Kakishita E: Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission.. Oncol Rep 6: 683-688, 1999.
APA
Tamura, S., Takemoto, Y., Takami, S., Kinoshita, M., Kumano, Y., Aono, H. ... Kakishita, E. (1999). Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission.. Oncology Reports, 6, 683-688. https://doi.org/10.3892/or.6.3.683
MLA
Tamura, S., Takemoto, Y., Takami, S., Kinoshita, M., Kumano, Y., Aono, H., Mori, M., Kakishita, E."Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission.". Oncology Reports 6.3 (1999): 683-688.
Chicago
Tamura, S., Takemoto, Y., Takami, S., Kinoshita, M., Kumano, Y., Aono, H., Mori, M., Kakishita, E."Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission.". Oncology Reports 6, no. 3 (1999): 683-688. https://doi.org/10.3892/or.6.3.683
Copy and paste a formatted citation
x
Spandidos Publications style
Tamura S, Takemoto Y, Takami S, Kinoshita M, Kumano Y, Aono H, Mori M and Kakishita E: Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission.. Oncol Rep 6: 683-688, 1999.
APA
Tamura, S., Takemoto, Y., Takami, S., Kinoshita, M., Kumano, Y., Aono, H. ... Kakishita, E. (1999). Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission.. Oncology Reports, 6, 683-688. https://doi.org/10.3892/or.6.3.683
MLA
Tamura, S., Takemoto, Y., Takami, S., Kinoshita, M., Kumano, Y., Aono, H., Mori, M., Kakishita, E."Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission.". Oncology Reports 6.3 (1999): 683-688.
Chicago
Tamura, S., Takemoto, Y., Takami, S., Kinoshita, M., Kumano, Y., Aono, H., Mori, M., Kakishita, E."Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission.". Oncology Reports 6, no. 3 (1999): 683-688. https://doi.org/10.3892/or.6.3.683
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