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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jul-Aug 1999 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The NM23 gene and its expression in oral squamous cell carcinoma.

  • Authors:
    • L Lo Muzio
    • M D Mignogna
    • G Pannone
    • S Staibano
    • M Procaccini
    • R Serpico
    • G De Rosa
    • C Scully

  • View Affiliations / Copyright

    Affiliations: Division of Oral Medicine and Pathology, University of Naples Federico II, Faculty of Medicine, Naples, Italy.
  • Pages: 747-798
    |
    Published online on: July 1, 1999
       https://doi.org/10.3892/or.6.4.747
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Abstract

The murine nm23, a putative metastasis suppressor, has three human homologues, NM23-H1, -H2, and -H3b. Several reports have suggested a low metastatic potential for neoplasms with a high expression of NM23-H1 gene, while other studies have not shown this relationship. These apparent differences in the role of NM23 in metastasis suppression might be explained by unability to discriminate between the expression of the two genes NM23-H1 and NM23-H2. The NM23-H2 product is not related to tumor progression and metastasis suppression. Two studies on human oral squamous cell carcinoma (OSCC) have been reported, both showing the NM23 product to be a metastasis suppressor factor. However, none of these two studies distinguished NM23-H1 from NM23-H2. The aim of this study was to detect the protein expression pattern of NM23-H1 product in 24 OSCCs by immunohistochemistry in paraffin-embedded tissues using a monoclonal antibody non-cross-reactive with NM23-H2. The NM23-H1 positive group showed lower frequency of lymph node metastasis, and a better grading than the NM23-H1 negative group supporting the role of NM23-H1 as metastasis suppressor factor which may be useful for predicting tumor metastasis in OSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Lo Muzio L, Mignogna M, Pannone G, Staibano S, Procaccini M, Serpico R, De Rosa G and Scully C: The NM23 gene and its expression in oral squamous cell carcinoma.. Oncol Rep 6: 747-798, 1999.
APA
Lo Muzio, L., Mignogna, M., Pannone, G., Staibano, S., Procaccini, M., Serpico, R. ... Scully, C. (1999). The NM23 gene and its expression in oral squamous cell carcinoma.. Oncology Reports, 6, 747-798. https://doi.org/10.3892/or.6.4.747
MLA
Lo Muzio, L., Mignogna, M., Pannone, G., Staibano, S., Procaccini, M., Serpico, R., De Rosa, G., Scully, C."The NM23 gene and its expression in oral squamous cell carcinoma.". Oncology Reports 6.4 (1999): 747-798.
Chicago
Lo Muzio, L., Mignogna, M., Pannone, G., Staibano, S., Procaccini, M., Serpico, R., De Rosa, G., Scully, C."The NM23 gene and its expression in oral squamous cell carcinoma.". Oncology Reports 6, no. 4 (1999): 747-798. https://doi.org/10.3892/or.6.4.747
Copy and paste a formatted citation
x
Spandidos Publications style
Lo Muzio L, Mignogna M, Pannone G, Staibano S, Procaccini M, Serpico R, De Rosa G and Scully C: The NM23 gene and its expression in oral squamous cell carcinoma.. Oncol Rep 6: 747-798, 1999.
APA
Lo Muzio, L., Mignogna, M., Pannone, G., Staibano, S., Procaccini, M., Serpico, R. ... Scully, C. (1999). The NM23 gene and its expression in oral squamous cell carcinoma.. Oncology Reports, 6, 747-798. https://doi.org/10.3892/or.6.4.747
MLA
Lo Muzio, L., Mignogna, M., Pannone, G., Staibano, S., Procaccini, M., Serpico, R., De Rosa, G., Scully, C."The NM23 gene and its expression in oral squamous cell carcinoma.". Oncology Reports 6.4 (1999): 747-798.
Chicago
Lo Muzio, L., Mignogna, M., Pannone, G., Staibano, S., Procaccini, M., Serpico, R., De Rosa, G., Scully, C."The NM23 gene and its expression in oral squamous cell carcinoma.". Oncology Reports 6, no. 4 (1999): 747-798. https://doi.org/10.3892/or.6.4.747
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