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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jul-Aug 1999 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Allelic loss on the short arm of chromosome 8 in oral squamous cell carcinoma.

  • Authors:
    • K Ono
    • A Miyakawa
    • M Fukuda
    • M Shiiba
    • K Uzawa
    • T Watanabe
    • T Miya
    • H Yokoe
    • Y Imai
    • H Tanzawa

  • View Affiliations / Copyright

    Affiliations: Department of Oral Surgery, School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan.
  • Pages: 785-794
    |
    Published online on: July 1, 1999
       https://doi.org/10.3892/or.6.4.785
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Abstract

Allelic deletions on the short arm of chromosome 8 (8p) are frequent events in many different types of malignant tumors, including head and neck tumors and oropharyngeal cancers. These regions are thought to harbor tumor suppressor genes. However, there has been no detailed analysis of loss of heterozygosity (LOH) on the chromosome arm 8p in oral squamous cell carcinoma (SCC). In order to estimate details of 8p loci involved in oral SCC, 32 patients with oral SCCs were examined for the LOH state 8p by PCR-LOH assay using 14 microsatellite markers. Based on our results a detailed deletion map of 8p showed LOH in at least one of the loci tested in 62.5% (20 of 32) of patients; and microsatellite instability (MI) was observed in 50% (16 of 32). The frequent LOH on this chromosome arm was identified at D8S87 and D8S258, mapped on 8p12 and 8p22, respectively. Fisher's exact test revealed no significant statistical correlation between the incidence of LOH or MI and clinicopathological features. Our observations indicate that the short arm of chromosome 8 may play a role in the pathogenesis of oral SCC; and that the two loci identified in this study may be tumor suppressor gene loci on 8p.

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Copy and paste a formatted citation
Spandidos Publications style
Ono K, Miyakawa A, Fukuda M, Shiiba M, Uzawa K, Watanabe T, Miya T, Yokoe H, Imai Y, Tanzawa H, Tanzawa H, et al: Allelic loss on the short arm of chromosome 8 in oral squamous cell carcinoma.. Oncol Rep 6: 785-794, 1999.
APA
Ono, K., Miyakawa, A., Fukuda, M., Shiiba, M., Uzawa, K., Watanabe, T. ... Tanzawa, H. (1999). Allelic loss on the short arm of chromosome 8 in oral squamous cell carcinoma.. Oncology Reports, 6, 785-794. https://doi.org/10.3892/or.6.4.785
MLA
Ono, K., Miyakawa, A., Fukuda, M., Shiiba, M., Uzawa, K., Watanabe, T., Miya, T., Yokoe, H., Imai, Y., Tanzawa, H."Allelic loss on the short arm of chromosome 8 in oral squamous cell carcinoma.". Oncology Reports 6.4 (1999): 785-794.
Chicago
Ono, K., Miyakawa, A., Fukuda, M., Shiiba, M., Uzawa, K., Watanabe, T., Miya, T., Yokoe, H., Imai, Y., Tanzawa, H."Allelic loss on the short arm of chromosome 8 in oral squamous cell carcinoma.". Oncology Reports 6, no. 4 (1999): 785-794. https://doi.org/10.3892/or.6.4.785
Copy and paste a formatted citation
x
Spandidos Publications style
Ono K, Miyakawa A, Fukuda M, Shiiba M, Uzawa K, Watanabe T, Miya T, Yokoe H, Imai Y, Tanzawa H, Tanzawa H, et al: Allelic loss on the short arm of chromosome 8 in oral squamous cell carcinoma.. Oncol Rep 6: 785-794, 1999.
APA
Ono, K., Miyakawa, A., Fukuda, M., Shiiba, M., Uzawa, K., Watanabe, T. ... Tanzawa, H. (1999). Allelic loss on the short arm of chromosome 8 in oral squamous cell carcinoma.. Oncology Reports, 6, 785-794. https://doi.org/10.3892/or.6.4.785
MLA
Ono, K., Miyakawa, A., Fukuda, M., Shiiba, M., Uzawa, K., Watanabe, T., Miya, T., Yokoe, H., Imai, Y., Tanzawa, H."Allelic loss on the short arm of chromosome 8 in oral squamous cell carcinoma.". Oncology Reports 6.4 (1999): 785-794.
Chicago
Ono, K., Miyakawa, A., Fukuda, M., Shiiba, M., Uzawa, K., Watanabe, T., Miya, T., Yokoe, H., Imai, Y., Tanzawa, H."Allelic loss on the short arm of chromosome 8 in oral squamous cell carcinoma.". Oncology Reports 6, no. 4 (1999): 785-794. https://doi.org/10.3892/or.6.4.785
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