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Loss of DNA-mismatch repair gene expression in oral melanomas.

  • Authors:
    • M Korabiowska
    • U Brinck
    • I Ruschenburg
    • J F Honig
    • J Stachura
    • M Droese

  • View Affiliations

  • Published online on: July 1, 1999     https://doi.org/10.3892/or.6.4.921
  • Pages: 921-924
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Abstract

The defect of DNA mismatch repair is postulated to be responsible for malignant transformation in many types of tumours. The main aim of this study was to evaluate the expression of DNA mismatch repair proteins in 29 cases of oral melanomas and to relate this to the ploidy status of the lesions. MLH1 expression was found in 4/29, MSH2 in 6/29, PMS2 in 2/29 and PMS1 in 0/29 cases investigated. The range of positively stained cells did not exceed 50% with MSH2, and PMS2, or 5% with MLH1. Loss of the DNA mismatch repair gene expression correlated with high aneuploidy ratio, observed in totally negative cases.

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Jul-Aug 1999
Volume 6 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Korabiowska M, Brinck U, Ruschenburg I, Honig J, Stachura J and Droese M: Loss of DNA-mismatch repair gene expression in oral melanomas.. Oncol Rep 6: 921-924, 1999
APA
Korabiowska, M., Brinck, U., Ruschenburg, I., Honig, J., Stachura, J., & Droese, M. (1999). Loss of DNA-mismatch repair gene expression in oral melanomas.. Oncology Reports, 6, 921-924. https://doi.org/10.3892/or.6.4.921
MLA
Korabiowska, M., Brinck, U., Ruschenburg, I., Honig, J., Stachura, J., Droese, M."Loss of DNA-mismatch repair gene expression in oral melanomas.". Oncology Reports 6.4 (1999): 921-924.
Chicago
Korabiowska, M., Brinck, U., Ruschenburg, I., Honig, J., Stachura, J., Droese, M."Loss of DNA-mismatch repair gene expression in oral melanomas.". Oncology Reports 6, no. 4 (1999): 921-924. https://doi.org/10.3892/or.6.4.921