Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.

  • Authors:
    • Y Hida
    • T Morita
    • M Fujita
    • Y Miyasaka
    • S Horita
    • Y Fujioka
    • K Nagashima
    • H Katoh
  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/or.6.5.1051
  • Pages: 1051-1057
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Abstract

Hepatocyte growth factor (HGF)/c-Met expression is known to be correlated with poor prognosis in several cancers. We investigated HGF/c-Met immunoreactivity and its correlation with clinical features in 51 patients with curatively resected extrahepatic biliary tract carcinoma. c-Met showed significant correlations with tumor location, T category, stage, perineural invasion and local recurrence. Overall survival in patients with HGF and c-Met immunopositivity was significantly worse than in those who were negative. Our findings suggest that HGF/c-Met play some roles in tumor development and that HGF/c-Met immunoreactivity could be a predictor of the mode of recurrence and poor prognosis.

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Sep-Oct 1999
Volume 6 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hida Y, Morita T, Fujita M, Miyasaka Y, Horita S, Fujioka Y, Nagashima K and Katoh H: Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.. Oncol Rep 6: 1051-1057, 1999
APA
Hida, Y., Morita, T., Fujita, M., Miyasaka, Y., Horita, S., Fujioka, Y. ... Katoh, H. (1999). Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.. Oncology Reports, 6, 1051-1057. https://doi.org/10.3892/or.6.5.1051
MLA
Hida, Y., Morita, T., Fujita, M., Miyasaka, Y., Horita, S., Fujioka, Y., Nagashima, K., Katoh, H."Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.". Oncology Reports 6.5 (1999): 1051-1057.
Chicago
Hida, Y., Morita, T., Fujita, M., Miyasaka, Y., Horita, S., Fujioka, Y., Nagashima, K., Katoh, H."Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.". Oncology Reports 6, no. 5 (1999): 1051-1057. https://doi.org/10.3892/or.6.5.1051