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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Sep-Oct 1999 Volume 6 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Inhibition of metastases by a serum factor associated to concomitant resistance induced by unrelated murine tumors.

  • Authors:
    • P Di Gianni
    • M Franco
    • R P Meiss
    • S Vanzulli
    • I Piazzon
    • C D Pasqualini
    • O D Bustuoabad
    • R A Ruggiero

  • View Affiliations / Copyright

    Affiliations: Division Medicina Experimental, Instituto de Investigaciones Hematologicas and Centro de Estudios Oncologicos, Academia Nacional de Medicina, 1425 Buenos Aires, Argentina.
  • Pages: 1073-1157
    |
    Published online on: September 1, 1999
       https://doi.org/10.3892/or.6.5.1073
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Abstract

Murine lung metatases growing undisturbed by the primary tumor were significantly inhibited by the concomitant resistance induced by a secondary subcutaneous implant of two unrelated tumors. Such inhibition was T-independent since it was also observed in nude mice; its full expression was dependent on the presence of the secondary tumor implant and it was exerted on both macroscopic and microscopic established metastases and not on the process of tumor cell dissemination from the primary tumor. Direct and indirect mechanisms seemed to be involved, the former affecting the metastatic cells per se by causing a decrease in proliferation and an increase in apoptosis while the latter affected neo-vascularization. These antitumor and antiangiogenic effects could be attributed to a serum factor induced by the unrelated tumors generating concomitant resistance. This factor proved to be heat, acid and alkaline resistant and dialysable; it was recovered in an HPLC column with maximum absorption at 215 and 266 nm; it was anionic at neutral pH, exhibiting free carboxil groups and one or more molecules of tyrosine, with a molecular weight between 870 and 1300 Dalton. Intravenous administration of this factor significantly inhibited lung metastases, decreasing mitosis and increasing apoptosis similar to that observed in the presence of the unrelated tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Di Gianni P, Franco M, Meiss R, Vanzulli S, Piazzon I, Pasqualini C, Bustuoabad O and Ruggiero R: Inhibition of metastases by a serum factor associated to concomitant resistance induced by unrelated murine tumors.. Oncol Rep 6: 1073-1157, 1999.
APA
Di Gianni, P., Franco, M., Meiss, R., Vanzulli, S., Piazzon, I., Pasqualini, C. ... Ruggiero, R. (1999). Inhibition of metastases by a serum factor associated to concomitant resistance induced by unrelated murine tumors.. Oncology Reports, 6, 1073-1157. https://doi.org/10.3892/or.6.5.1073
MLA
Di Gianni, P., Franco, M., Meiss, R., Vanzulli, S., Piazzon, I., Pasqualini, C., Bustuoabad, O., Ruggiero, R."Inhibition of metastases by a serum factor associated to concomitant resistance induced by unrelated murine tumors.". Oncology Reports 6.5 (1999): 1073-1157.
Chicago
Di Gianni, P., Franco, M., Meiss, R., Vanzulli, S., Piazzon, I., Pasqualini, C., Bustuoabad, O., Ruggiero, R."Inhibition of metastases by a serum factor associated to concomitant resistance induced by unrelated murine tumors.". Oncology Reports 6, no. 5 (1999): 1073-1157. https://doi.org/10.3892/or.6.5.1073
Copy and paste a formatted citation
x
Spandidos Publications style
Di Gianni P, Franco M, Meiss R, Vanzulli S, Piazzon I, Pasqualini C, Bustuoabad O and Ruggiero R: Inhibition of metastases by a serum factor associated to concomitant resistance induced by unrelated murine tumors.. Oncol Rep 6: 1073-1157, 1999.
APA
Di Gianni, P., Franco, M., Meiss, R., Vanzulli, S., Piazzon, I., Pasqualini, C. ... Ruggiero, R. (1999). Inhibition of metastases by a serum factor associated to concomitant resistance induced by unrelated murine tumors.. Oncology Reports, 6, 1073-1157. https://doi.org/10.3892/or.6.5.1073
MLA
Di Gianni, P., Franco, M., Meiss, R., Vanzulli, S., Piazzon, I., Pasqualini, C., Bustuoabad, O., Ruggiero, R."Inhibition of metastases by a serum factor associated to concomitant resistance induced by unrelated murine tumors.". Oncology Reports 6.5 (1999): 1073-1157.
Chicago
Di Gianni, P., Franco, M., Meiss, R., Vanzulli, S., Piazzon, I., Pasqualini, C., Bustuoabad, O., Ruggiero, R."Inhibition of metastases by a serum factor associated to concomitant resistance induced by unrelated murine tumors.". Oncology Reports 6, no. 5 (1999): 1073-1157. https://doi.org/10.3892/or.6.5.1073
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