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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Sep-Oct 1999 Volume 6 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression analysis of multidrug resistance associated genes in neuroblastomas.

  • Authors:
    • P Bader
    • F Schilling
    • M Schlaud
    • R Girgert
    • R Handgretinger
    • T Klingebiel
    • J Treuner
    • C Liu
    • D Niethammer
    • J F Beck

  • View Affiliations / Copyright

    Affiliations: Children's Hospital, Department of Hematology and Oncology, D-72076 Tubingen, Germany.
  • Pages: 1143-1149
    |
    Published online on: September 1, 1999
       https://doi.org/10.3892/or.6.5.1143
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Abstract

In a series of 40 neuroblastomas we analyzed the relative mRNA levels of the MDR associated genes encoding MDR1/P-glycoprotein (MDR1), multidrug resistance associated protein (MRP), lung cancer resistance related protein (LRP) and topoisomerase IIalpha (TOPO IIalpha) by cDNA-PCR. Cyclin A (CYCA) was included to examine cellular proliferation activity. MYCN gene expression was analyzed as it was recently shown to be associated with enhanced MRP gene expression in neuroblastomas. We found that tumors with MYCN gene amplification exhibit significantly increased MYCN and MRP gene expression levels. Tumors with an allelic loss of the chromosomal 1p region showed significant (P<0.05) lower MDR1 gene expression (MDR1: 50+/-29, n=4) than tumors without (MDR1: 117+/-81, P<0.05, n=36). Moreover, significant positive correlations were found for MYCN/TOPO IIalpha (P<0.0001), MYCN/CYCA (P<0.05), TOPO IIalpha/CYCA (P<0.01), MRP/CYCA (P<0.0001) and MRP/LRP (P<0.05). Our results give evidence that MDR in neuroblastomas might be caused by multiple resistance factors and that a higher proliferation rate of neuroblastoma cells possibly based on altered MYCN gene expression is associated with enhanced MRP, CYCA and TOPO IIalpha gene expression.

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Copy and paste a formatted citation
Spandidos Publications style
Bader P, Schilling F, Schlaud M, Girgert R, Handgretinger R, Klingebiel T, Treuner J, Liu C, Niethammer D, Beck J, Beck J, et al: Expression analysis of multidrug resistance associated genes in neuroblastomas.. Oncol Rep 6: 1143-1149, 1999.
APA
Bader, P., Schilling, F., Schlaud, M., Girgert, R., Handgretinger, R., Klingebiel, T. ... Beck, J. (1999). Expression analysis of multidrug resistance associated genes in neuroblastomas.. Oncology Reports, 6, 1143-1149. https://doi.org/10.3892/or.6.5.1143
MLA
Bader, P., Schilling, F., Schlaud, M., Girgert, R., Handgretinger, R., Klingebiel, T., Treuner, J., Liu, C., Niethammer, D., Beck, J."Expression analysis of multidrug resistance associated genes in neuroblastomas.". Oncology Reports 6.5 (1999): 1143-1149.
Chicago
Bader, P., Schilling, F., Schlaud, M., Girgert, R., Handgretinger, R., Klingebiel, T., Treuner, J., Liu, C., Niethammer, D., Beck, J."Expression analysis of multidrug resistance associated genes in neuroblastomas.". Oncology Reports 6, no. 5 (1999): 1143-1149. https://doi.org/10.3892/or.6.5.1143
Copy and paste a formatted citation
x
Spandidos Publications style
Bader P, Schilling F, Schlaud M, Girgert R, Handgretinger R, Klingebiel T, Treuner J, Liu C, Niethammer D, Beck J, Beck J, et al: Expression analysis of multidrug resistance associated genes in neuroblastomas.. Oncol Rep 6: 1143-1149, 1999.
APA
Bader, P., Schilling, F., Schlaud, M., Girgert, R., Handgretinger, R., Klingebiel, T. ... Beck, J. (1999). Expression analysis of multidrug resistance associated genes in neuroblastomas.. Oncology Reports, 6, 1143-1149. https://doi.org/10.3892/or.6.5.1143
MLA
Bader, P., Schilling, F., Schlaud, M., Girgert, R., Handgretinger, R., Klingebiel, T., Treuner, J., Liu, C., Niethammer, D., Beck, J."Expression analysis of multidrug resistance associated genes in neuroblastomas.". Oncology Reports 6.5 (1999): 1143-1149.
Chicago
Bader, P., Schilling, F., Schlaud, M., Girgert, R., Handgretinger, R., Klingebiel, T., Treuner, J., Liu, C., Niethammer, D., Beck, J."Expression analysis of multidrug resistance associated genes in neuroblastomas.". Oncology Reports 6, no. 5 (1999): 1143-1149. https://doi.org/10.3892/or.6.5.1143
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