Influence of concomitant miso or NaCl treatment on induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in rats.

Watanabe,H; Uesaka,T; Kido,S; Ishimura,Y; Shiraki,K; Kuramoto,K; Hirata,S; Shoji,S; Katoh,O; Fujimoto,N

doi:10.3892/or.6.5.989

Influence of concomitant miso or NaCl treatment on induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in rats.

Authors:
- H Watanabe
- T Uesaka
- S Kido
- Y Ishimura
- K Shiraki
- K Kuramoto
- S Hirata
- S Shoji
- O Katoh
- N Fujimoto
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Affiliations: Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan.
Published online on: September 1, 1999 https://doi.org/10.3892/or.6.5.989
Pages: 989-1082

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Abstract

Six-week old male Sprague-Dawley (CD) rats were treated with 100 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 16 weeks in their drinking water with control, miso or sodium chloride (NaCl) supplemented diets. All animals were autopsied 12 months after the beginning of the MNNG treatment. Despite higher intake of MNNG in the high dose miso and NaCl groups, the total tumor incidences were decreased compared to middle and lowest values. The glandular stomach adenocarcinoma incidences in the 10% and 5% miso groups were significantly decreased as compared to those in the 2.2% or 1.1% NaCl groups, with the same concentration of NaCl.