The immunopotentiation effects of the bifunctional radiosensitizer KIN-806 in comparison with its analogs KIN-804 and KIN-844.

  • Authors:
    • T Inomata
    • Y Ogawa
    • A Nishioka
    • N Hamada
    • S Ito
    • S Kariya
    • S Yoshida
    • H Nagasawa
    • H Hori
    • S Inayama
  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/or.6.6.1209
  • Pages: 1209-1221
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Abstract

KIN-806 is one of the 2-nitroimidazole derivative hypoxic cell radiosensitizers. Its radiosensitizing effects and the degree of lung metastasis detected were evaluated and compared with its analogs KIN-804 and KIN-844. The immune reactions induced by these radiosensitizers were also analyzed. Female C3H/He mice and SCCVII tumor cells were used. Seventeen days after inoculation of SCCVII tumor cells into the animals, 0.4 g/kg of KIN-806, KIN-804, and KIN-844 was administered to each radiosensitizer group 30 min before 40 Gy was delivered as local irradiation. In each group, KIN-806, KIN-804, and KIN-844 markedly suppressed tumor regrowth in comparison with animals that received irradiation alone. There was no significant difference in the radiosensitizing effects among these three radiosensitizers. A marked suppression of lung metastasis and macrophage/T-lymphocyte infiltration into the tumor were observed only in the KIN-806-administered groups, regardless of the presence or absence of radiation therapy. It therefore appears likely that the lung metastasis suppression was caused by the immune reaction elicited by KIN-806, which is an excellent immunopotentiator as well as an effective radiosensitizer.

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Nov-Dec 1999
Volume 6 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Inomata T, Ogawa Y, Nishioka A, Hamada N, Ito S, Kariya S, Yoshida S, Nagasawa H, Hori H, Inayama S, Inayama S, et al: The immunopotentiation effects of the bifunctional radiosensitizer KIN-806 in comparison with its analogs KIN-804 and KIN-844.. Oncol Rep 6: 1209-1221, 1999
APA
Inomata, T., Ogawa, Y., Nishioka, A., Hamada, N., Ito, S., Kariya, S. ... Inayama, S. (1999). The immunopotentiation effects of the bifunctional radiosensitizer KIN-806 in comparison with its analogs KIN-804 and KIN-844.. Oncology Reports, 6, 1209-1221. https://doi.org/10.3892/or.6.6.1209
MLA
Inomata, T., Ogawa, Y., Nishioka, A., Hamada, N., Ito, S., Kariya, S., Yoshida, S., Nagasawa, H., Hori, H., Inayama, S."The immunopotentiation effects of the bifunctional radiosensitizer KIN-806 in comparison with its analogs KIN-804 and KIN-844.". Oncology Reports 6.6 (1999): 1209-1221.
Chicago
Inomata, T., Ogawa, Y., Nishioka, A., Hamada, N., Ito, S., Kariya, S., Yoshida, S., Nagasawa, H., Hori, H., Inayama, S."The immunopotentiation effects of the bifunctional radiosensitizer KIN-806 in comparison with its analogs KIN-804 and KIN-844.". Oncology Reports 6, no. 6 (1999): 1209-1221. https://doi.org/10.3892/or.6.6.1209