Potentiation by 2-deoxy-D-glucose tetraacetate of the antitumoral action of 5-fluorouracil in mice inoculated with L1210 ascites-producing cells.

  • Authors:
    • E Olivares
    • M M Kadiata
    • W J Malaisse
  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/or.6.6.1309
  • Pages: 1309-1320
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Abstract

Ascites-producing tumoral cells of the L1210 line were inoculated to syngenic mice. The gain in body weight and survival time were measured in untreated animals and mice injected intraperitoneally 1, 5 and 9 days after the administration of the tumoral cells with 5-fluorouracil (20-200 microg/g body wt.) and/or 2-deoxy-D-glucose tetraacetate (75 or 1,350 microg/g body wt.). The two agents failed to affect adversely the growth of control mice not inoculated with the tumoral cells. 5-fluorouracil caused a dose-related decrease in the body weight gain caused by the occurrence of the tumoral ascites and a dose-related prolongation of survival time. Although 2-deoxy-D-glucose tetraacetate, when tested in the low dose of 75 microg/g body weight opposed the effect of 5-fluorouracil on survival time, a higher dose of the ester (1,350 microg/g body weight) potentiated the effect of 5-fluorouracil to both decrease body weight gain and increase survival time. It is proposed, therefore, that 2-deoxy-D-glucose tetraacetate could be used to increase the cytostatic action of classical chemotherapeutic agents in the treatment of neoplastic diseases.

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Nov-Dec 1999
Volume 6 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Olivares E, Kadiata M and Malaisse W: Potentiation by 2-deoxy-D-glucose tetraacetate of the antitumoral action of 5-fluorouracil in mice inoculated with L1210 ascites-producing cells.. Oncol Rep 6: 1309-1320, 1999.
APA
Olivares, E., Kadiata, M., & Malaisse, W. (1999). Potentiation by 2-deoxy-D-glucose tetraacetate of the antitumoral action of 5-fluorouracil in mice inoculated with L1210 ascites-producing cells.. Oncology Reports, 6, 1309-1320. https://doi.org/10.3892/or.6.6.1309
MLA
Olivares, E., Kadiata, M., Malaisse, W."Potentiation by 2-deoxy-D-glucose tetraacetate of the antitumoral action of 5-fluorouracil in mice inoculated with L1210 ascites-producing cells.". Oncology Reports 6.6 (1999): 1309-1320.
Chicago
Olivares, E., Kadiata, M., Malaisse, W."Potentiation by 2-deoxy-D-glucose tetraacetate of the antitumoral action of 5-fluorouracil in mice inoculated with L1210 ascites-producing cells.". Oncology Reports 6, no. 6 (1999): 1309-1320. https://doi.org/10.3892/or.6.6.1309