The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay.
- K A Hartmann
- U M Carl
- P Sminia
- G Lammering
- K A Becker
- G Schmitt
Affiliations: Department of Radiation Oncology, University of Dusseldorf, D-40225 Dusseldorf, Germany.
- Published online on: January 1, 2000 https://doi.org/10.3892/or.7.1.131
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We investigated the ischemia-reperfusion-induced tumour growth delay as a function of ischemic time, tumour temperature, and the amount of inspired oxygen during reperfusion. The rhabdomyosarcoma R1H growing on the right flank of male WAG/Rij rats was clamped for 2 or 4 h at 20 degrees C or 37 degrees C. Five minutes prior to and 10 min during reperfusion the animals respired air, pure oxygen or carbogen (95% O2, 5% CO2). Comparison of single treatment modalities with untreated controls revealed significant tumour growth delays after clamping times of 4 h at 37 degrees C for air and pure oxygen, but not for carbogen.