Clofazimine and B4121 sensitize an intrinsically resistant human colon cancer cell line to P-glycoprotein substrates.

  • Authors:
    • C E van Rensburg
    • G K Joone
    • J F O'Sullivan
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  • Published online on: January 1, 2000     https://doi.org/10.3892/or.7.1.193
  • Pages: 193-198
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Abstract

The potential of B4121 to sensitize three intrinsically resistant human colon cancer cell lines (CaCo2, ATCC HTB 37; COLO 32 DM, ATCC CCL 220; HT-29, ATCC HTB 38) to vinblastine, doxorubicin, daunorubicin, paclitaxel, taxotere and cisplatin at a non-toxic, therapeutically relevant concentration of 0.25 microg/ml was compared with that of clofazimine at a similar concentration. The cell line expressing high levels of P-glycoprotein (P-gp), COLO 320 DM, was susceptible to chemosensitization by the experimental agents for the P-gp substrates (paclitaxel, taxotere, daunorubicin, vinblastine and doxorubicin) but not for cisplatin. CaCo2 cells expressed lower levels of P-gp and were only marginally susceptible to sensitization by any one of these drugs, except in the case of sensitization by B4121 for doxorubicin and taxotere, whereas the HT-29, a P-gp negative cell line, was unaffected. The riminophenazines, especially B4121, might prove useful as combination treatment in circumventing P-gp mediated resistance of colon cancers.

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Jan-Feb 2000
Volume 7 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
van Rensburg C, Joone G and O'Sullivan J: Clofazimine and B4121 sensitize an intrinsically resistant human colon cancer cell line to P-glycoprotein substrates.. Oncol Rep 7: 193-198, 2000
APA
van Rensburg, C., Joone, G., & O'Sullivan, J. (2000). Clofazimine and B4121 sensitize an intrinsically resistant human colon cancer cell line to P-glycoprotein substrates.. Oncology Reports, 7, 193-198. https://doi.org/10.3892/or.7.1.193
MLA
van Rensburg, C., Joone, G., O'Sullivan, J."Clofazimine and B4121 sensitize an intrinsically resistant human colon cancer cell line to P-glycoprotein substrates.". Oncology Reports 7.1 (2000): 193-198.
Chicago
van Rensburg, C., Joone, G., O'Sullivan, J."Clofazimine and B4121 sensitize an intrinsically resistant human colon cancer cell line to P-glycoprotein substrates.". Oncology Reports 7, no. 1 (2000): 193-198. https://doi.org/10.3892/or.7.1.193