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In vivo chemosensitivity of human malignant cystosarcoma phyllodes xenografts.

  • Authors:
    • Y Ueyama
    • Y Abe
    • Y Ohnishi
    • N Sawa
    • H Hatanaka
    • A Handa
    • Y Tokuda
    • H Yamazaki
    • H Kijima
    • N Tamaoki
    • M Nakamura

  • View Affiliations

  • Published online on: March 1, 2000     https://doi.org/10.3892/or.7.2.257
  • Pages: 257-317
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Malignant cystosarcoma phyllodes (MCSP) is a rare breast tumor. Chemotherapeutic regimens for treatment of MCSP have not been established. We previously established an MCSP xenograft line MC-3-JCK. In this study, we established a new MCSP xenograft line, MC-10-JCK, by serial transplantation in nude mice. We studied the chemosensitivity of these two MCSP tumor xenografts to anticancer drugs in vivo. We also examined the expression of multidrug resistance-related proteins such as p-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) by immunohistochemical analysis. These two xenografts were sensitive to doxorubicin, vincristine and cyclophosphamide in vivo. Immunohistochemically, clinical specimens and xenografts were negative for Pgp and MRP expression. These results are consistent with the chemosensitivity of human MCSP to lipophilic anticancer compounds.

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Mar-Apr 2000
Volume 7 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Ueyama Y, Abe Y, Ohnishi Y, Sawa N, Hatanaka H, Handa A, Tokuda Y, Yamazaki H, Kijima H, Tamaoki N, Tamaoki N, et al: In vivo chemosensitivity of human malignant cystosarcoma phyllodes xenografts.. Oncol Rep 7: 257-317, 2000
APA
Ueyama, Y., Abe, Y., Ohnishi, Y., Sawa, N., Hatanaka, H., Handa, A. ... Nakamura, M. (2000). In vivo chemosensitivity of human malignant cystosarcoma phyllodes xenografts.. Oncology Reports, 7, 257-317. https://doi.org/10.3892/or.7.2.257
MLA
Ueyama, Y., Abe, Y., Ohnishi, Y., Sawa, N., Hatanaka, H., Handa, A., Tokuda, Y., Yamazaki, H., Kijima, H., Tamaoki, N., Nakamura, M."In vivo chemosensitivity of human malignant cystosarcoma phyllodes xenografts.". Oncology Reports 7.2 (2000): 257-317.
Chicago
Ueyama, Y., Abe, Y., Ohnishi, Y., Sawa, N., Hatanaka, H., Handa, A., Tokuda, Y., Yamazaki, H., Kijima, H., Tamaoki, N., Nakamura, M."In vivo chemosensitivity of human malignant cystosarcoma phyllodes xenografts.". Oncology Reports 7, no. 2 (2000): 257-317. https://doi.org/10.3892/or.7.2.257