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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Mar-Apr 2000 Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo.

  • Authors:
    • K Hayakawa
    • M Hasegawa
    • M Kawashima
    • Y Nakamura
    • M Matsuura
    • H Toda
    • N Mitsuhashi
    • H Niibe

  • View Affiliations / Copyright

    Affiliations: Department of Radiology and Radiation Oncology, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan.
  • Pages: 267-337
    |
    Published online on: March 1, 2000
       https://doi.org/10.3892/or.7.2.267
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Abstract

The effects of doxorubicin and radiation on apoptosis, p53 expression, and tumor growth in human tumor xenografts were investigated. Human ependymoblastoma (NNE), primitive neuroectodermal tumor (YKP), glioblastoma (KYG) and small cell lung carcinoma (GLS) that are all transplantable to nude mice were treated with doxorubicin (8 mg/kg) or radiation (1 Gy). The histological study was performed by using TUNEL and p53 staining. Cytotoxic effects of doxorubicin and radiation were compared with no-treatment group by the growth curves and apoptotic index of tumor to each treatment. In NNE with wild-type p53, doxorubicin induced growth delay of tumors (tumor volume doubling time; 13.7+/-3.3 days in control group vs 30.4+/-1.5 days in doxorubicin group), but no growth delay of tumors in KYG and GLS with mutant type p53. While radiation-induced apoptosis appeared most frequently at 6 h after irradiation, doxorubicin-induced apoptosis had a tendency to appear later. Furthermore, although the frequency of doxorubicin-induced apoptosis was lower than that of apoptosis by 1 Gy irradiation, apoptotic cells appeared for many hours after the treatment. Doxorubicin-induced apoptosis may be correlated with p53 phenotype because apoptosis was induced only in tumor with wild-type p53, but it appeared less frequently and later than radiation-induced apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Hayakawa K, Hasegawa M, Kawashima M, Nakamura Y, Matsuura M, Toda H, Mitsuhashi N and Niibe H: Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo.. Oncol Rep 7: 267-337, 2000.
APA
Hayakawa, K., Hasegawa, M., Kawashima, M., Nakamura, Y., Matsuura, M., Toda, H. ... Niibe, H. (2000). Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo.. Oncology Reports, 7, 267-337. https://doi.org/10.3892/or.7.2.267
MLA
Hayakawa, K., Hasegawa, M., Kawashima, M., Nakamura, Y., Matsuura, M., Toda, H., Mitsuhashi, N., Niibe, H."Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo.". Oncology Reports 7.2 (2000): 267-337.
Chicago
Hayakawa, K., Hasegawa, M., Kawashima, M., Nakamura, Y., Matsuura, M., Toda, H., Mitsuhashi, N., Niibe, H."Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo.". Oncology Reports 7, no. 2 (2000): 267-337. https://doi.org/10.3892/or.7.2.267
Copy and paste a formatted citation
x
Spandidos Publications style
Hayakawa K, Hasegawa M, Kawashima M, Nakamura Y, Matsuura M, Toda H, Mitsuhashi N and Niibe H: Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo.. Oncol Rep 7: 267-337, 2000.
APA
Hayakawa, K., Hasegawa, M., Kawashima, M., Nakamura, Y., Matsuura, M., Toda, H. ... Niibe, H. (2000). Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo.. Oncology Reports, 7, 267-337. https://doi.org/10.3892/or.7.2.267
MLA
Hayakawa, K., Hasegawa, M., Kawashima, M., Nakamura, Y., Matsuura, M., Toda, H., Mitsuhashi, N., Niibe, H."Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo.". Oncology Reports 7.2 (2000): 267-337.
Chicago
Hayakawa, K., Hasegawa, M., Kawashima, M., Nakamura, Y., Matsuura, M., Toda, H., Mitsuhashi, N., Niibe, H."Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo.". Oncology Reports 7, no. 2 (2000): 267-337. https://doi.org/10.3892/or.7.2.267
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