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Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma.

  • Authors:
    • M Kadota
    • Y Tamaki
    • I Sakita
    • Y Komoike
    • M Miyazaki
    • M Ooka
    • N Masuda
    • Y Fujiwara
    • T Ohnishi
    • N Tomita
    • M Sekimoto
    • M Ohue
    • T Ikeda
    • T Kobayashi
    • A Horii
    • M Monden

  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/or.7.3.529
  • Pages: 529-562
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Abstract

A total of 17 primary thyroid cancer specimens including seven anaplastic cancers, two papillary cancers adjacent to the anaplastic cancers, and eight papillary cancers were analyzed for loss of heterozygosity (LOH) on chromosome arm 16p. All tumors of anaplastic cancer showed LOHs at one or more loci, and a 7-cM region of the smallest deleted region was found on 16p13.3 between D16S423 and D16S406. This LOH was specifically found in the anaplastic cancer and not in the papillary thyroid cancer. Our present results suggest localization of the putative tumor suppressor gene on 16p13.3, which is likely to play an important role in the anaplastic transformation of thyroid cancer.

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May-Jun 2000
Volume 7 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • CiteScore: 8.4
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Spandidos Publications style
Kadota M, Tamaki Y, Sakita I, Komoike Y, Miyazaki M, Ooka M, Masuda N, Fujiwara Y, Ohnishi T, Tomita N, Tomita N, et al: Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma.. Oncol Rep 7: 529-562, 2000
APA
Kadota, M., Tamaki, Y., Sakita, I., Komoike, Y., Miyazaki, M., Ooka, M. ... Monden, M. (2000). Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma.. Oncology Reports, 7, 529-562. https://doi.org/10.3892/or.7.3.529
MLA
Kadota, M., Tamaki, Y., Sakita, I., Komoike, Y., Miyazaki, M., Ooka, M., Masuda, N., Fujiwara, Y., Ohnishi, T., Tomita, N., Sekimoto, M., Ohue, M., Ikeda, T., Kobayashi, T., Horii, A., Monden, M."Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma.". Oncology Reports 7.3 (2000): 529-562.
Chicago
Kadota, M., Tamaki, Y., Sakita, I., Komoike, Y., Miyazaki, M., Ooka, M., Masuda, N., Fujiwara, Y., Ohnishi, T., Tomita, N., Sekimoto, M., Ohue, M., Ikeda, T., Kobayashi, T., Horii, A., Monden, M."Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma.". Oncology Reports 7, no. 3 (2000): 529-562. https://doi.org/10.3892/or.7.3.529