Identification of occult micrometastases in patients with early gastric cancer using anti-cytokeratin monoclonal antibodies.

  • Authors:
    • L Saragoni
    • M Gaudio
    • P Morgagni
    • S Folli
    • F Bazzocchi
    • E Scarpi
    • A Saragoni
  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/or.7.3.535
  • Pages: 535-544
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Abstract

The presence of occult micrometastases was evaluated in 1488 lymph nodes removed from 139 patients with node-negative early gastric cancer (EGC). Additional multiple levels of the lymph nodes were examined with haematoxylin-eosin staining and keratin immunostaining. Occult nodal micrometastases were detected in 24 patients (17%) in one or more lymph nodes dissected after a gastrectomy. The cases investigated were a small group from a total of 412 EGC patients who underwent surgical treatment in our hospital between 1976 and 1997; the mean follow-up period was 9 years (range 1-22). We found no significant differences between cytokeratin-negative and positive patients regarding the following clinicopathological parameters: age, gender, tumour size and site, macroscopic and microscopic type, depth of invasion and type of infiltration, according to Kodama's classification. The survival rate at 5 years was 88% and 87% for cytokeratin-negative and positive patients, respectively (log-rank = 0.6; ns). Our data suggest that occult micrometastases do not add useful information and immunohistochemical studies to detect them are probably unnecessary.

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May-Jun 2000
Volume 7 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Saragoni L, Gaudio M, Morgagni P, Folli S, Bazzocchi F, Scarpi E and Saragoni A: Identification of occult micrometastases in patients with early gastric cancer using anti-cytokeratin monoclonal antibodies.. Oncol Rep 7: 535-544, 2000
APA
Saragoni, L., Gaudio, M., Morgagni, P., Folli, S., Bazzocchi, F., Scarpi, E., & Saragoni, A. (2000). Identification of occult micrometastases in patients with early gastric cancer using anti-cytokeratin monoclonal antibodies.. Oncology Reports, 7, 535-544. https://doi.org/10.3892/or.7.3.535
MLA
Saragoni, L., Gaudio, M., Morgagni, P., Folli, S., Bazzocchi, F., Scarpi, E., Saragoni, A."Identification of occult micrometastases in patients with early gastric cancer using anti-cytokeratin monoclonal antibodies.". Oncology Reports 7.3 (2000): 535-544.
Chicago
Saragoni, L., Gaudio, M., Morgagni, P., Folli, S., Bazzocchi, F., Scarpi, E., Saragoni, A."Identification of occult micrometastases in patients with early gastric cancer using anti-cytokeratin monoclonal antibodies.". Oncology Reports 7, no. 3 (2000): 535-544. https://doi.org/10.3892/or.7.3.535