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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-Jun 2000 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.

  • Authors:
    • H Tanaka
    • Y Shimada
    • H Harada
    • M Shinoda
    • S Hatooka
    • M Imamura
    • K Ishizaki

  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya 464-8681, Japan.
  • Pages: 591-594
    |
    Published online on: May 1, 2000
       https://doi.org/10.3892/or.7.3.591
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Abstract

Allelic loss of the short arm of chromosome 3 is common in esophageal squamous cell carcinoma (ESC) and its premalignant lesions. The ARP gene (Arginine Rich Protein) was mapped to 3p21, and frequent variations of the triplet, AGG, repeat around codon 50 of the ARP gene were reported in a variety of human cancers. To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues. Sequence variants were observed in four ESC tumours; two (AGG)2 insertions, one ATG50-to-AGG substitution and one AGG deletion. However, they were also found in its corresponding normal tissues, suggesting that variation of the ARP gene found in ESC is polymorphic. We next analyzed sequence changes in 48 unrelated Japanese healthy individuals. They consist of 33 wild-type homozygotes, nine (AGG)2 insertion/wild-type heterozygotes, two (AGG)2 insertion homozygotes, one AGG deletion/wild-type heterozygote and three ATG50-to-AGG substitution/wild-type heterozygotes. Allele frequencies for wild-type, (AGG)2 insertion, ATG50-to-AGG substitution and AGG deletion are 0.82, 0.14, 0.03 and 0.01, respectively. Observed genotype frequencies fit well with the Hardy-Weinberg's law. Significant difference was not observed between allele distributions in normal and cancer patient populations.

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Copy and paste a formatted citation
Spandidos Publications style
Tanaka H, Shimada Y, Harada H, Shinoda M, Hatooka S, Imamura M and Ishizaki K: Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.. Oncol Rep 7: 591-594, 2000.
APA
Tanaka, H., Shimada, Y., Harada, H., Shinoda, M., Hatooka, S., Imamura, M., & Ishizaki, K. (2000). Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.. Oncology Reports, 7, 591-594. https://doi.org/10.3892/or.7.3.591
MLA
Tanaka, H., Shimada, Y., Harada, H., Shinoda, M., Hatooka, S., Imamura, M., Ishizaki, K."Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.". Oncology Reports 7.3 (2000): 591-594.
Chicago
Tanaka, H., Shimada, Y., Harada, H., Shinoda, M., Hatooka, S., Imamura, M., Ishizaki, K."Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.". Oncology Reports 7, no. 3 (2000): 591-594. https://doi.org/10.3892/or.7.3.591
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka H, Shimada Y, Harada H, Shinoda M, Hatooka S, Imamura M and Ishizaki K: Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.. Oncol Rep 7: 591-594, 2000.
APA
Tanaka, H., Shimada, Y., Harada, H., Shinoda, M., Hatooka, S., Imamura, M., & Ishizaki, K. (2000). Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.. Oncology Reports, 7, 591-594. https://doi.org/10.3892/or.7.3.591
MLA
Tanaka, H., Shimada, Y., Harada, H., Shinoda, M., Hatooka, S., Imamura, M., Ishizaki, K."Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.". Oncology Reports 7.3 (2000): 591-594.
Chicago
Tanaka, H., Shimada, Y., Harada, H., Shinoda, M., Hatooka, S., Imamura, M., Ishizaki, K."Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.". Oncology Reports 7, no. 3 (2000): 591-594. https://doi.org/10.3892/or.7.3.591
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