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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-Jun 2000 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis.

  • Authors:
    • T Mitamura
    • S Sakamoto
    • S Suzuki
    • S Yoshimura
    • M Maemura
    • H Kudo

  • View Affiliations / Copyright

    Affiliations: Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
  • Pages: 599-1200
    |
    Published online on: May 1, 2000
       https://doi.org/10.3892/or.7.3.599
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Abstract

Lentinan; i.e., polysaccharides extracted from a kind of black mushroom shiitake, has been clinically applied as an antitumor and antimetastatic drug, and has been reported to prevent both chemical and viral carcinogenesis. It is known that lentinan affects the tumorous vascular system resulting in the induction of hemorrhagic necrosis which is dependent on T-cells in the tumor. Repeated mucosal necrosis-regeneration sequence in chronic ulcerative colitis induced with 3% dextran sulfate sodium led to colorectal carcinogenesis in azoxymethane-pretreated mice. In the present study, the additive treatment with lentinan in the azoxymethane-dextran sulfate sodium treated mice enhanced the colorectal high-grade dysplasia, though not significantly, and the splenic weight. This may show the proliferation of pathogenic splenic T cells resulting in a change for the worse of ulcerative colitis, anemia induced with hemorrhage and colorectal carcinogenesis; i.e., high-grade dysplasia of the mucosa and/or invasive adenocarcinomas of the colorectum. The present results may recommend chemoimmunotherapy while using lentinan, but not immunotherapy using lentinan alone, is indicated for the management of cancer patients.

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Copy and paste a formatted citation
Spandidos Publications style
Mitamura T, Sakamoto S, Suzuki S, Yoshimura S, Maemura M and Kudo H: Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis.. Oncol Rep 7: 599-1200, 2000.
APA
Mitamura, T., Sakamoto, S., Suzuki, S., Yoshimura, S., Maemura, M., & Kudo, H. (2000). Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis.. Oncology Reports, 7, 599-1200. https://doi.org/10.3892/or.7.3.599
MLA
Mitamura, T., Sakamoto, S., Suzuki, S., Yoshimura, S., Maemura, M., Kudo, H."Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis.". Oncology Reports 7.3 (2000): 599-1200.
Chicago
Mitamura, T., Sakamoto, S., Suzuki, S., Yoshimura, S., Maemura, M., Kudo, H."Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis.". Oncology Reports 7, no. 3 (2000): 599-1200. https://doi.org/10.3892/or.7.3.599
Copy and paste a formatted citation
x
Spandidos Publications style
Mitamura T, Sakamoto S, Suzuki S, Yoshimura S, Maemura M and Kudo H: Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis.. Oncol Rep 7: 599-1200, 2000.
APA
Mitamura, T., Sakamoto, S., Suzuki, S., Yoshimura, S., Maemura, M., & Kudo, H. (2000). Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis.. Oncology Reports, 7, 599-1200. https://doi.org/10.3892/or.7.3.599
MLA
Mitamura, T., Sakamoto, S., Suzuki, S., Yoshimura, S., Maemura, M., Kudo, H."Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis.". Oncology Reports 7.3 (2000): 599-1200.
Chicago
Mitamura, T., Sakamoto, S., Suzuki, S., Yoshimura, S., Maemura, M., Kudo, H."Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis.". Oncology Reports 7, no. 3 (2000): 599-1200. https://doi.org/10.3892/or.7.3.599
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