Prognostic value of simultaneous expression of p21 and mdm2 in breast carcinomas treated by adjuvant chemotherapy with antracyclin.

  • Authors:
    • M P Mathoulin-Portier
    • P Viens
    • D Cowen
    • F Bertucci
    • G Houvenaeghel
    • J Geneix
    • B Puig
    • V J Bardou
    • J Jacquemier
  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/or.7.3.675
  • Pages: 675-755
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Abstract

One hundred and sixty-two breast carcinomas treated by adjuvant chemotherapy were investigated in immunohistochemistry for expression of p53 and two wild-type p53-regulated induced proteins, mdm2 and p21/waf1. p21 and mdm2 were expression stongly correlated with Ki67 but not with survival. The p53+/p21+, p53+/p21- and p53+/mdm2- phenotypes were associated with the worst prognosis. The p53+/p21+/ mdm2+ tumors were associated with a better outcome than the other phenotypes, they may be tumors expressing wild-type p53 and p21, and a form of mdm2 that might lead to the stabilization of p53. It is suggested that p21/mdm2 expression should be investigated in all cases of p53 positive breast cancer.

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May-Jun 2000
Volume 7 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Mathoulin-Portier M, Viens P, Cowen D, Bertucci F, Houvenaeghel G, Geneix J, Puig B, Bardou V and Jacquemier J: Prognostic value of simultaneous expression of p21 and mdm2 in breast carcinomas treated by adjuvant chemotherapy with antracyclin.. Oncol Rep 7: 675-755, 2000
APA
Mathoulin-Portier, M., Viens, P., Cowen, D., Bertucci, F., Houvenaeghel, G., Geneix, J. ... Jacquemier, J. (2000). Prognostic value of simultaneous expression of p21 and mdm2 in breast carcinomas treated by adjuvant chemotherapy with antracyclin.. Oncology Reports, 7, 675-755. https://doi.org/10.3892/or.7.3.675
MLA
Mathoulin-Portier, M., Viens, P., Cowen, D., Bertucci, F., Houvenaeghel, G., Geneix, J., Puig, B., Bardou, V., Jacquemier, J."Prognostic value of simultaneous expression of p21 and mdm2 in breast carcinomas treated by adjuvant chemotherapy with antracyclin.". Oncology Reports 7.3 (2000): 675-755.
Chicago
Mathoulin-Portier, M., Viens, P., Cowen, D., Bertucci, F., Houvenaeghel, G., Geneix, J., Puig, B., Bardou, V., Jacquemier, J."Prognostic value of simultaneous expression of p21 and mdm2 in breast carcinomas treated by adjuvant chemotherapy with antracyclin.". Oncology Reports 7, no. 3 (2000): 675-755. https://doi.org/10.3892/or.7.3.675