Protein kinase C activity in human gastric carcinoma.

  • Authors:
    • N Uchida
    • S Okamura
    • H Kuwano
  • View Affiliations

  • Published online on: July 1, 2000     https://doi.org/10.3892/or.7.4.793
  • Pages: 793-799
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Abstract

Protein kinase C (PKC) is believed to play an important role in tumorigenesis, so we measured PKC activities of human gastric carcinomas and adjacent normal mucosae to elucidate its role for gastric carcinogenesis using PegTagtrade mark non-radioactive protein kinase C assay. The mean activities of microsomal PKC in carcinoma and normal mucosa were 449+/-179, 661+/-264 pmol/min/mg, respectively (p=0.001). Cancerous microsomal PKC activity decreased when the tumor was small, node-metastasis was negative, the depth of invasion was shallow and the histological type was differentiated. Our results suggested that PKC activity would be down-regulated in membrane of the early stage of gastric carcinoma.

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Jul-Aug 2000
Volume 7 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Uchida N, Okamura S and Kuwano H: Protein kinase C activity in human gastric carcinoma.. Oncol Rep 7: 793-799, 2000
APA
Uchida, N., Okamura, S., & Kuwano, H. (2000). Protein kinase C activity in human gastric carcinoma.. Oncology Reports, 7, 793-799. https://doi.org/10.3892/or.7.4.793
MLA
Uchida, N., Okamura, S., Kuwano, H."Protein kinase C activity in human gastric carcinoma.". Oncology Reports 7.4 (2000): 793-799.
Chicago
Uchida, N., Okamura, S., Kuwano, H."Protein kinase C activity in human gastric carcinoma.". Oncology Reports 7, no. 4 (2000): 793-799. https://doi.org/10.3892/or.7.4.793