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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Sep-Oct 2000 Volume 7 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Octreotide treatment suppresses malignant somatotrophic pituitary tumor cell growth in rats.

  • Authors:
    • H Kondo
    • H Takino
    • K Akino
    • H Yamasaki
    • Y Yamaguchi
    • M Ito
    • K Eguchi

  • View Affiliations / Copyright

    Affiliations: The First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan.
  • Pages: 965-974
    |
    Published online on: September 1, 2000
       https://doi.org/10.3892/or.7.5.965
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Abstract

We have recently established an in vitro cell line (metastatic mGH3) derived from lymph node metastases of the rat pituitary somatotroph. Here we examined the in vivo effects of octreotide, a somatostatin analog, against malignant pituitary tumors. Wistar-Furth rats (n=8) were inoculated subcutaneously with mGH3 cells while control rats received injections of equal volumes of the vehicle only. Four rats were treated with octreotide three times daily while another group of four rats were treated with saline only. After 6 weeks of treatment, histopathological and immunohistological analyses were performed. The tumor weights of rats treated with octreotide were significantly lighter than those of untreated rats. All rats implanted mGH3, but not administered treatment, developed inguinal lymph node metastases, whereas none of those implanted mGH3 and treated with octreotide developed such metastases. The proportion of PCNA-stained tumor cells was higher in tumors of untreated rats than in those of octreotide-treated rats. However, the proportion of apoptotic cells in the tumor was not different between treated and untreated rats. Our results suggest that octreotide might be potentially effective for invasive and malignant human pituitary tumors by regulating the tumor cell cycle.

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Copy and paste a formatted citation
Spandidos Publications style
Kondo H, Takino H, Akino K, Yamasaki H, Yamaguchi Y, Ito M and Eguchi K: Octreotide treatment suppresses malignant somatotrophic pituitary tumor cell growth in rats.. Oncol Rep 7: 965-974, 2000.
APA
Kondo, H., Takino, H., Akino, K., Yamasaki, H., Yamaguchi, Y., Ito, M., & Eguchi, K. (2000). Octreotide treatment suppresses malignant somatotrophic pituitary tumor cell growth in rats.. Oncology Reports, 7, 965-974. https://doi.org/10.3892/or.7.5.965
MLA
Kondo, H., Takino, H., Akino, K., Yamasaki, H., Yamaguchi, Y., Ito, M., Eguchi, K."Octreotide treatment suppresses malignant somatotrophic pituitary tumor cell growth in rats.". Oncology Reports 7.5 (2000): 965-974.
Chicago
Kondo, H., Takino, H., Akino, K., Yamasaki, H., Yamaguchi, Y., Ito, M., Eguchi, K."Octreotide treatment suppresses malignant somatotrophic pituitary tumor cell growth in rats.". Oncology Reports 7, no. 5 (2000): 965-974. https://doi.org/10.3892/or.7.5.965
Copy and paste a formatted citation
x
Spandidos Publications style
Kondo H, Takino H, Akino K, Yamasaki H, Yamaguchi Y, Ito M and Eguchi K: Octreotide treatment suppresses malignant somatotrophic pituitary tumor cell growth in rats.. Oncol Rep 7: 965-974, 2000.
APA
Kondo, H., Takino, H., Akino, K., Yamasaki, H., Yamaguchi, Y., Ito, M., & Eguchi, K. (2000). Octreotide treatment suppresses malignant somatotrophic pituitary tumor cell growth in rats.. Oncology Reports, 7, 965-974. https://doi.org/10.3892/or.7.5.965
MLA
Kondo, H., Takino, H., Akino, K., Yamasaki, H., Yamaguchi, Y., Ito, M., Eguchi, K."Octreotide treatment suppresses malignant somatotrophic pituitary tumor cell growth in rats.". Oncology Reports 7.5 (2000): 965-974.
Chicago
Kondo, H., Takino, H., Akino, K., Yamasaki, H., Yamaguchi, Y., Ito, M., Eguchi, K."Octreotide treatment suppresses malignant somatotrophic pituitary tumor cell growth in rats.". Oncology Reports 7, no. 5 (2000): 965-974. https://doi.org/10.3892/or.7.5.965
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