Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines.

  • Authors:
    • K Yoshioka
    • T Kataoka
    • T Hayashi
    • M Hasegawa
    • Y Ishi
    • H Hibasami
  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/or.7.6.1221
  • Pages: 1221-1224
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Abstract

Antitumor effects of gallic acid on human stomach cancer KATO III cells and human colon adenocarcinoma COLO 205 cells were investigated. The exposures of KATO III and COLO 205 cells to gallic acid led to both growth inhibition and induction of apoptosis. Morphological changes showing apoptotic bodies were observed in both the cell lines treated with gallic acid. The fragmentations by gallic acid of DNA to oligonucleosomal-sized fragments, that are characteristics of apoptosis, were observed to be concentration- and time-dependent. These findings suggest that growth inhibitions by gallic acid of KATO III cells and COLO 205 cells result from the apoptosis induced by gallic acid. Thus, gallic acid might be a candidate drug for digestive gut cancer treatment to overcome the resistance to chemotherapeutic drugs.

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Nov-Dec 2000
Volume 7 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yoshioka K, Kataoka T, Hayashi T, Hasegawa M, Ishi Y and Hibasami H: Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines.. Oncol Rep 7: 1221-1224, 2000
APA
Yoshioka, K., Kataoka, T., Hayashi, T., Hasegawa, M., Ishi, Y., & Hibasami, H. (2000). Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines.. Oncology Reports, 7, 1221-1224. https://doi.org/10.3892/or.7.6.1221
MLA
Yoshioka, K., Kataoka, T., Hayashi, T., Hasegawa, M., Ishi, Y., Hibasami, H."Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines.". Oncology Reports 7.6 (2000): 1221-1224.
Chicago
Yoshioka, K., Kataoka, T., Hayashi, T., Hasegawa, M., Ishi, Y., Hibasami, H."Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines.". Oncology Reports 7, no. 6 (2000): 1221-1224. https://doi.org/10.3892/or.7.6.1221