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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January-February 2001 Volume 8 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2001 Volume 8 Issue 1

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Article

The circulating auto-antibodies to p53 protein in the follow-up of lymphoma patients.

  • Authors:
    • B Jezersek
    • Z Rudolf
    • S Novakovic

  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Institute of Oncology, 1000 Ljubljana, Slovenia. snovakovic@onko-i.si
  • Pages: 77-158
    |
    Published online on: January 1, 2001
       https://doi.org/10.3892/or.8.1.77
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Abstract

Mutant p53 proteins may be targets of the host immune system - consequently a certain proportion of cancer patients (the percentage varies according to the type of cancer) with tumors that carry p53 missense mutations develop circulating p53 antibodies. The present study was aimed at defining the occurrence of circulating antibodies to p53 protein in patients with various types of non-Hodgkin's lymphomas (NHL). Altogether, the sera of 108 cases with various histological types of NHL and of 20 healthy controls were assessed for the presence of antibodies to p53 protein with an ELISA method. In 73 cases of NHL, also the immunohistochemical staining for p53 antigen was performed to make a rough estimation of the frequency of mutational events. The development of autoantibodies to p53 protein was observed in approximately 7% of NHL patients (predominantly in the more aggressive variants of the disease, but also in one case of small lymphocytic lymphoma). This proportion represents roughly one third of the number of patients assessed (immunohistochemically) to carry a missense p53 mutation in their tumors. The autoantibodies to p53 protein can be used as a tumor marker (early appearance, high specificity) in the follow-up of a subset of NHL patients, but, unfortunately, this subset comprises only approximately 7% of NHL patients.

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Copy and paste a formatted citation
Spandidos Publications style
Jezersek B, Rudolf Z and Novakovic S: The circulating auto-antibodies to p53 protein in the follow-up of lymphoma patients.. Oncol Rep 8: 77-158, 2001.
APA
Jezersek, B., Rudolf, Z., & Novakovic, S. (2001). The circulating auto-antibodies to p53 protein in the follow-up of lymphoma patients.. Oncology Reports, 8, 77-158. https://doi.org/10.3892/or.8.1.77
MLA
Jezersek, B., Rudolf, Z., Novakovic, S."The circulating auto-antibodies to p53 protein in the follow-up of lymphoma patients.". Oncology Reports 8.1 (2001): 77-158.
Chicago
Jezersek, B., Rudolf, Z., Novakovic, S."The circulating auto-antibodies to p53 protein in the follow-up of lymphoma patients.". Oncology Reports 8, no. 1 (2001): 77-158. https://doi.org/10.3892/or.8.1.77
Copy and paste a formatted citation
x
Spandidos Publications style
Jezersek B, Rudolf Z and Novakovic S: The circulating auto-antibodies to p53 protein in the follow-up of lymphoma patients.. Oncol Rep 8: 77-158, 2001.
APA
Jezersek, B., Rudolf, Z., & Novakovic, S. (2001). The circulating auto-antibodies to p53 protein in the follow-up of lymphoma patients.. Oncology Reports, 8, 77-158. https://doi.org/10.3892/or.8.1.77
MLA
Jezersek, B., Rudolf, Z., Novakovic, S."The circulating auto-antibodies to p53 protein in the follow-up of lymphoma patients.". Oncology Reports 8.1 (2001): 77-158.
Chicago
Jezersek, B., Rudolf, Z., Novakovic, S."The circulating auto-antibodies to p53 protein in the follow-up of lymphoma patients.". Oncology Reports 8, no. 1 (2001): 77-158. https://doi.org/10.3892/or.8.1.77
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