Clinicopathologic study on cholangiolocellular carcinoma

  • Authors:
    • Koji Shiota
    • Jun Taguchi
    • Osamu Nakashima
    • Miwako Nakashima
    • Masamichi Kojiro
  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/or.8.2.263
  • Pages: 263-268
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Abstract

We clinicopathologically studied 6 resected cases of cholangiolocarcinoma (CLC) including 2 referred cases from other hospitals. The frequency of CLC was 0.56% of the 708 consecutively resected cases of primary liver cancer and the mean age of CLC cases was 66 years. Three of the 6 cases (50%) were hepatitis C virus antibody (HCVab) positive, one (17%) was hepatitis B virus surface antigen (HBsAg) positive, and 2 (33%) were negative to both HCVAb and HBsAg. Serum levels of α-fetoprotein were slightly elavated only in 1 case. Clinically, 4 cases were diagnosed as hepatocellular carcinoma (HCC) and 2 cases as cholangiocellular carcinoma (CCC). Grossly, CLCs were whitish in color and solid, not encapsulated, and resembled CCC. Histologically, the tumor cells had eosinophilic cytoplasm with ovoid nuclei, and mild atypia. The tumor proliferated in an anastomosing pattern of Hering's canal-like small glands with an abundant fibrous stroma. Four of the 6 tumors (83%) consisted of only CLC and other 2 tumors contained CCC-like area and HCC-like area in a part of the nodules, respectively. Immunohistochemically, all tumors were positive to cytokeratin (CK) 7. CK8 were also positive in all of 6 cases. These results revealed that CLC had the clinical features resembling HCC but the morphologic features resembling CCC. It is suggested that CLC cells might be derived from Hering's canal or stem cells which have the intermediate features between hepatocytes and bile duct epithelium.

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March-April 2001
Volume 8 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Shiota K, Taguchi J, Nakashima O, Nakashima M and Kojiro M: Clinicopathologic study on cholangiolocellular carcinoma. Oncol Rep 8: 263-268, 2001
APA
Shiota, K., Taguchi, J., Nakashima, O., Nakashima, M., & Kojiro, M. (2001). Clinicopathologic study on cholangiolocellular carcinoma. Oncology Reports, 8, 263-268. https://doi.org/10.3892/or.8.2.263
MLA
Shiota, K., Taguchi, J., Nakashima, O., Nakashima, M., Kojiro, M."Clinicopathologic study on cholangiolocellular carcinoma". Oncology Reports 8.2 (2001): 263-268.
Chicago
Shiota, K., Taguchi, J., Nakashima, O., Nakashima, M., Kojiro, M."Clinicopathologic study on cholangiolocellular carcinoma". Oncology Reports 8, no. 2 (2001): 263-268. https://doi.org/10.3892/or.8.2.263