c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma

  • Authors:
    • T. Hiyama
    • K. Haruma
    • Y. Kitadai
    • M. Ito
    • H. Masuda
    • M. Miyamoto
    • S. Tanaka
    • M. Yoshihara
    • K. Sumii
    • F. Shimamoto
    • K. Chayama
  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/or.8.2.289
  • Pages: 289-292
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Abstract

The c-myc gene is involved in important cellular processes, including cell proliferation, differentiation, and apoptosis. We analyzed mutation of the c-myc gene in 51 patients with gastric lymphoma [27 patients with low-grade mucosa-associated lymphoid tissue (MALT) lymphoma, 11 with high-grade MALT lymphoma, and 13 with diffuse large B-cell lymphoma (DLL)], by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. We also evaluated the relationship between mutation of the c-myc gene and regression of low-grade MALT lymphoma after Helicobacter pylori (H. pylori) eradication. Mutation in exon 2 of the c-myc gene was present in 2 of 20 (10%) patients with low-grade MALT lymphoma, in 1 of 7 (14%) patients with high-grade MALT lymphoma, and none of 10 patients with DLL. The 3 patients who had mutations of the gene, showed different patterns of mobility shift, suggesting different mutations. In addition, 15 patients with low-grade MALT lymphoma received anti-H. pylori therapy. All the patients achieved eradication. Nine of the 15 (60%) patients with low-grade MALT lymphoma showed complete regression (CR), 3 (20%) showed partial regression (PR), and 3 (20%) showed no change (NC). One of the 9 (11%) CR patients had a mutation of the c-myc gene. None of the 3 PR and 3 NC patients had mutation of the gene. There was no significant difference between the frequencies among the c-myc gene mutation in CR, in PR and in NC patients. These data suggest that mutation of the c-myc gene may not be commonly associated with development of gastric MALT lymphoma and DLL, and may not be associated with regression of low-grade MALT lymphoma after H. pylori eradication.

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March-April 2001
Volume 8 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hiyama T, Haruma K, Kitadai Y, Ito M, Masuda H, Miyamoto M, Tanaka S, Yoshihara M, Sumii K, Shimamoto F, Shimamoto F, et al: c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma. Oncol Rep 8: 289-292, 2001.
APA
Hiyama, T., Haruma, K., Kitadai, Y., Ito, M., Masuda, H., Miyamoto, M. ... Chayama, K. (2001). c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma. Oncology Reports, 8, 289-292. https://doi.org/10.3892/or.8.2.289
MLA
Hiyama, T., Haruma, K., Kitadai, Y., Ito, M., Masuda, H., Miyamoto, M., Tanaka, S., Yoshihara, M., Sumii, K., Shimamoto, F., Chayama, K."c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma". Oncology Reports 8.2 (2001): 289-292.
Chicago
Hiyama, T., Haruma, K., Kitadai, Y., Ito, M., Masuda, H., Miyamoto, M., Tanaka, S., Yoshihara, M., Sumii, K., Shimamoto, F., Chayama, K."c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma". Oncology Reports 8, no. 2 (2001): 289-292. https://doi.org/10.3892/or.8.2.289