Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma

  • Authors:
    • Yuichiro Sakamoto
    • Yoshihiko Kitajima
    • Genichiro Edakuni
    • Eizaburo Sasatomi
    • Michito Mori
    • Kenji Kitahara
    • Kohji Miyazaki
  • View Affiliations

  • Published online on: May 1, 2001     https://doi.org/10.3892/or.8.3.477
  • Pages: 477-484
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a widely known severe malignancy with a poor prognosis. Perineural invasion extending to the extra-pancreatic nerve plexus, a significant concern in the treatment is frequently present in this cancer. We analyzed immunohistochemical expression of neurotrophins (NGF, BDNF, NT-3) and the cognate receptors, Trk tyrosine kinase receptor family (TrkA, B, C) and p75NGFR in 28 surgically resected PDAC specimens. A comparative study between several clinicopathologic factors and Trk receptors revealed a significant correlation between increased expression of TrkA and cancer proliferation, as well as TrkC and cancer invasion, including venous and perineural invasion. The present findings revealed a novel mechanism in PDAC progression that is mediated via a NTs-Trk interaction.

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May-June 2001
Volume 8 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sakamoto Y, Kitajima Y, Edakuni G, Sasatomi E, Mori M, Kitahara K and Miyazaki K: Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma. Oncol Rep 8: 477-484, 2001
APA
Sakamoto, Y., Kitajima, Y., Edakuni, G., Sasatomi, E., Mori, M., Kitahara, K., & Miyazaki, K. (2001). Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma. Oncology Reports, 8, 477-484. https://doi.org/10.3892/or.8.3.477
MLA
Sakamoto, Y., Kitajima, Y., Edakuni, G., Sasatomi, E., Mori, M., Kitahara, K., Miyazaki, K."Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma". Oncology Reports 8.3 (2001): 477-484.
Chicago
Sakamoto, Y., Kitajima, Y., Edakuni, G., Sasatomi, E., Mori, M., Kitahara, K., Miyazaki, K."Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma". Oncology Reports 8, no. 3 (2001): 477-484. https://doi.org/10.3892/or.8.3.477