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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-June 2001 Volume 8 Issue 3

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Recombinant PAI-1 inhibits angiogenesis and reduces size of LNCaP prostate cancer xenografts in SCID mice

R. Swiercz, Rick W. Keck, E. Skrzypczak-Jankun, S. H. Selman, J. Jankun
Pages: 463-470
Published online on: 01 May 2001

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Article

Inverse correlation of apoptotic and angiogenic markers in squamous cell carcinoma of the head and neck

Frank Riedel, Karl Gotte, Wolfgang Bergler, Karl Hormann
Pages: 471-476
Published online on: 01 May 2001

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Article

Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma

Yuichiro Sakamoto, Yoshihiko Kitajima, Genichiro Edakuni, Eizaburo Sasatomi, Michito Mori, Kenji Kitahara, Kohji Miyazaki
Pages: 477-484
Published online on: 01 May 2001

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Article

MUC1 and MUC2 expression in human gallbladder carcinoma: A clinicopathological study and relationship with prognosis

H. Kashiwagi, H. Kijima, S. Dowaki, Y. Ohtani, K. Tobita, H. Yamazaki, M. Nakamura, Y. Ueyama, M. Tanaka, S. Inokuchi, H. Makuuchi
Pages: 485-489
Published online on: 01 May 2001

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Article

Biological role of thymidine phosphorylase in human astrocytic tumors

Koji Tanioka, Hideo Takeshima, Hirofumi Hirano, Takahiro Kimura, Shun-ichi Nagata, Shin-ichi Akiyama, Jun-ichi Kuratsu
Pages: 491-496
Published online on: 01 May 2001

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Article

Molecular markers and prediction of response to chemoradiation in rectal cancer

Adaora Okonkwo, Srinidhi Musunuri, Mark Talamonti, Al Benson, William Small, Steven J. Stryker, M. Sambasiva Rao
Pages: 497-500
Published online on: 01 May 2001

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Article

Hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines with different radiothermosensitivity in vitro

Mohammad Shahidul Islam, Norio Mitsuhashi, Tetsuo Akimoto, Hideyuki Sakurai, Masatoshi Hasegawa, Hitoshi Ishikawa, Hideo Niibe
Pages: 501-507
Published online on: 01 May 2001

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Article

p53 mutation found to be a significant prognostic indicator in distal colorectal cancer

R. Okubo, H. Masuda, N. Nemoto
Pages: 509-514
Published online on: 01 May 2001

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Article

Progression of prostate cancer: Diagnostic and prognostic utility of prostate-specific antigen, α2-macroglobulin, and their complexes

Yuhsaku Kanoh, Nobuhisa Ohtani, Tadashi Ohara, Takaomi Mashiko, Shinichi Ohtani, Shin Egawa, Shiro Baba, Hideki Ohtani
Pages: 515-519
Published online on: 01 May 2001

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Article

The complementary role of β-catenin in diagnosing various subtypes of renal cell carcinomas and its up-regulation in conventional renal cell carcinomas with high nuclear grades

Limei Guo, Naoto Kuroda, Eriko Miyazaki, Yoshihiro Hayashi, Makoto Toi, Keishi Naruse, Makoto Hiroi, Shingo Ashida, Taro Shuin, Hideaki Enzan
Pages: 521-526
Published online on: 01 May 2001

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Article

Membrane fluidity correlates with liver cancer cell proliferation and infiltration potential

N. O. Funaki, J. Tanaka, M. Kohmoto, T. Sugiyama, G. Ohshio, A. Nonaka, F. Yotsumoto, Y. Takeda, M. Imamura
Pages: 527-532
Published online on: 01 May 2001

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Article

P53 mutations in Ewing's sarcoma

Yong-Koo Park, Sung Gil Chi, Youn-Wha Kim, Hye-Rim Park, K. Krishnan Unni
Pages: 533-537
Published online on: 01 May 2001

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Article

Heparanase expression in clinical digestive malignancies

Hiroshi Inoue, Koshi Mimori, Toru Utsunomiya, Noriaki Sadanaga, Graham F. Barnard, Hiroaki Ueo, Masaki Mori
Pages: 539-542
Published online on: 01 May 2001

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Article

Effect of a combined administration of 5-fluorouracil and medroxyprogesterone acetate on pyrimidine nucleoside phosphorylases and thymidylate synthetase in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors

M. Nagasawa, Y. Iino, Y. Koibuchi, T. Andoh, Y. Morishita
Pages: 543-546
Published online on: 01 May 2001

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Article

Correlation of DNA synthesis-inhibiting activity and the extent of transmembrane permeation into tumor cells by unsaturated or saturated fatty alcohols of graded chain-length upon hyperthermia

Yoshie Takada, Katsuhiro Kageyama, Ryusaku Yamada, Yasuto Onoyama, Toshibumi Nakajima, Masako Hosono, Nobuhiko Miwa
Pages: 547-551
Published online on: 01 May 2001

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Article

Ewing's sarcoma of bone: Relation between clinical characteristics and staging

Stefano Ferrari, Franco Bertoni, Mario Mercuri, Sandra Sottili, Michela Versari, Gaetano Bacci
Pages: 553-556
Published online on: 01 May 2001

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Article

Abnormal expression of pan-ras, c-myc and tp53 in squamous cell carcinoma of cervix: correlation with HPV and prognosis

H. Y.S. Ngan, A. N.Y. Cheung, S. S. Liu, D. K.L. Cheng, T. Y. Ng, L. C. Wong
Pages: 557-561
Published online on: 01 May 2001

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Article

Transformation-associated changes in gene expression of alternative splicing regulatory factors in mouse fibroblast cells

Takashi Maeda, Souhei Furukawa
Pages: 563-566
Published online on: 01 May 2001

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Article

Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer

N. Takai, T. Miyazaki, K. Fujisawa, K. Nasu, I. Miyakawa
Pages: 567-573
Published online on: 01 May 2001

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Article

Obstructive jaundice facilitates hepatic metastasis of B16F1 mouse melanoma cells: participation of increased VCAM-1 expression in the liver

Hirofumi Kishimoto, Kotaro Sasahara, Kazumaro Yamazaki, Takuya Nagata, Hideyuki Uotani, Iwao Yamashita, Katsunori Tauchi, Kazuhiro Tsukada
Pages: 575-578
Published online on: 01 May 2001

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Article

Oncoprotein changes in the flat lesions with atypia and invasive neoplasms of the urinary bladder

Keun H. Kee, Mi J. Lee, Jae Y. Ro
Pages: 579-583
Published online on: 01 May 2001

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Article

Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma

Shinsuke Takeno, Tsuyoshi Noguchi, Ryuichi Kikuchi, Shinsuke Wada, Tetsuro Sato, Yuzo Uchida
Pages: 585-590
Published online on: 01 May 2001

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Article

Immunohistochemical investigation of S100A9 expression in pulmonary adenocarcinoma: S100A9 expression is associated with tumor differentiation

Kazumori Arai, Takumi Teratani, Ryushi Nozawa, Toshihiro Yamada
Pages: 591-596
Published online on: 01 May 2001

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Article

A phase II trial of mitomycin C, 5'-deoxy-5-fluorouridine, etoposide and medroxyprogesterone acetate (McVD-MPA) as a salvage chemotherapy to anthracycline-resistant tumor in relapsed breast cancer and its mechanism(s) of antitumor action

R. Kim, A. Osaki, K. Tanabe, J. Kojima, T. Toge
Pages: 597-603
Published online on: 01 May 2001

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Article

Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer

K. Katano, S. Tsujitani, M. Maeta, K. Fukuda, S. Oka, K. Hisamitsu, M. Ikeguchi, N. Kaibara
Pages: 605-609
Published online on: 01 May 2001

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Article

Doxorubicin cardiotoxicity in children: Reduced incidence of cardiac dysfunction associated with continuous-infusion schedules

Su G. Berrak, Michael S. Ewer, Norman Jaffe, Peggy Pearson, Hubert Ried, Hallie A. Zietz, Robert S. Benjamin
Pages: 611-614
Published online on: 01 May 2001

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Article

Mitochondrial genotypes and radiation-induced micronucleus formation in human osteosarcoma cells in vitro

Ken Yoshida, Hideya Yamazaki, Shuji Ozeki, Takehiro Inoue, Yasuo Yoshioka, Makoto Yoneda, Yoshisada Fujiwara, Toshihiko Inoue
Pages: 615-619
Published online on: 01 May 2001

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Article

Dihydropyrimidine dehydrogenase activity of cancerous and non-cancerous tissues in liver and large intestine

Masahide Ikeguchi, Yasuaki Hirooka, Masato Makino, Nobuaki Kaibara
Pages: 621-625
Published online on: 01 May 2001

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Article

Further evidence that altered p16/CDKN2 gene expression is associated with lymph node metastasis in squamous cell carcinoma of the esophagus

Hiroya Takeuchi, Soji Ozawa, Nobutoshi Ando, Yuko Kitagawa, Makio Mukai, Masakazu Ueda, Masaki Kitajima
Pages: 627-632
Published online on: 01 May 2001

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Article

Reduction in the incidence of Helicobacter pylori-associated carcinoma in Japanese young adults

Masanori Ito, Ken Haruma, Tomoari Kamada, Yasuhiko Kitadai, Toru Hidaka, Toshitaka Tsuda, Hironao Komatsu, Toshiyuki Fukuhara, Masaharu Yoshihara, Kazuaki Chayama
Pages: 633-636
Published online on: 01 May 2001

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Article

Wild-type p53 gene transfection in human cultured sarcomas: Effect of CDDP

Koji Endo, Itaru Kuratate, Mari Watanabe, Haruhiko Yoshida, Ryota Teshima, Mitsuhiko Osaki, Hisao Ito
Pages: 637-642
Published online on: 01 May 2001

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Article

A new bisphosphonate treatment option for giant cell tumors

N. Fujimoto, K. Nakagawa, A. Seichi, A. Terahara, M. Tago, Y. Aoki, Y. Hosoi, K. Ohtomo
Pages: 643-647
Published online on: 01 May 2001

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Article

Dysregulation of telomerase activity and expression in lymphokine-activated killer cells from advanced cancer patients: Possible involvement in cancer-associated immunosuppression mechanism

K. Minami, Y. Yamaguchi, K. Yoshida, C. P. Quan, T. Toge
Pages: 649-653
Published online on: 01 May 2001

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Article

Inverse association of non-steroidal anti-inflammatory drugs and malignant melanoma among women

Randall E. Harris, Joanne Beebe-Donk, Kadambari K. Namboodiri
Pages: 655-657
Published online on: 01 May 2001

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Article

Breast cancer during the HIV epidemic in an African population

Hassan Amir, Cyprian Makwaya, Fred Mhalu, Martin P. Mbonde, Reinhard Schwartz-Albiez
Pages: 659-661
Published online on: 01 May 2001

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Article

Regulation of BRCA1 and BRCA2 transcript in response to cisplatin, adriamycin, taxol and ionising radiation is correlated to p53 functional status in ovarian cancer cell lines

Benedicte Aunoble, Dominique Bernard-Gallon, Yves-Jean Bignon
Pages: 663-668
Published online on: 01 May 2001

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Article

Fetal fibronectin: A new screening-marker for bladder cancer?

H. Wunderlich, O. Reichelt, D.-H. Zermann, J. Schubert, A. Berndt, H. Kosmehl
Pages: 669-672
Published online on: 01 May 2001

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Article

Prolongation of survival of rats injected with hepatoma cells treated by nuclei extracts from mouse and rat embryo cells

G. Berger, C. Frayssinet, M. Berger, C. Lafarge Frayssinet
Pages: 673-677
Published online on: 01 May 2001

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Article

Quinoxaline 1,4-dioxides as anticancer and hypoxia-selective drugs

Hala U. Gali-Muhtasib, Makhluf J. Haddadin, Dina N. Rahhal, Ihab H. Younes
Pages: 679-684
Published online on: 01 May 2001

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Article

Relation of prenephrectomy CD profiles and serum cytokines to the disease outcome and response to IFN-α/IL-2 therapy in renal cell carcinoma patients

Ludmila Lauerova, Ladislav Dusek, Vladimir Spurny, Marta Simickova, Arne Rovny, Ales Rejthar, Ivo Kocak, Jan Kovarik
Pages: 685-692
Published online on: 01 May 2001

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Article

Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia

Nathalie Henriques Silva, Glicinia Pimenta, Wolmar Alcantara Pulcheri, Marcia Vasconcellos Fournier, Nelson Spector, M. G. da Costa Carvalho
Pages: 693-696
Published online on: 01 May 2001

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Article

An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer

Junichi Sakamoto, Susumu Kodaira, Chikuma Hamada, Katsuki Ito, Yoshihiko Maehara, Hiroshi Takagi, Keizo Sugimachi, Hiroaki Nakazato, Yasuo Ohashi
Pages: 697-703
Published online on: 01 May 2001

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Journal Cover
September-2026 Volume 56 Issue 3

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and suppressing Wnt/β‑catenin signaling

Jianwei Sun, Haifeng Liang, Yan Zhang, Ding Ding, Qian Xiang, Mengyang Zheng, Pengyue Zhang
Article Number: 163
Published online on: 23 July 2026

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Review Open Access

Multidimensional molecular mechanisms of drug resistance in breast cancer: Implications for clinical decision‑making and treatment strategies (Review)

Wenya Xu, Shiyao Kang, Shaochen Xin, Yanbin Wu, Yuan Zhao, Miaomiao Sheng
Article Number: 162
Published online on: 22 July 2026

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Review Open Access

XPO1: From basic research to clinical treatment (Review)

Changyan Yang, Jing Zhu, Xiang Zheng, Xiaochen Hou, Jiumei Zhao, Youfu Pan, Yu Tang
Article Number: 161
Published online on: 22 July 2026

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Retraction Open Access

[Retracted] Methylation and intratumoural heterogeneity of 14‑3‑3 σ in oral cancer

Ujjal Kumar Bhawal, Keiichi Tsukinoki, Tomonori Sasahira, Fuyuki Sato, Yusuke Mori, Noriko Muto, Masaru Sugiyama, Hiroki Kuniyasu
Article Number: 160
Published online on: 20 July 2026

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Article Open Access

M2‑TAM‑derived exosomal miR‑491‑3p modulates UBE2D3 and promotes the proliferation, migration and invasion of lung cancer cells

Qiang Zhang, Yungang Sun, Yu Zhuang, Shiwei Xu, Mengxu Yao, Siyang Jiao, Qi Wang, Feng Shao, Xiaoying Zhang
Article Number: 159
Published online on: 17 July 2026

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Correction Open Access

[Corrigendum] Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway

Qingkai Zhang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Hailong Li, Dong Shang
Article Number: 158
Published online on: 15 July 2026

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Article Open Access

TM6SF2 overexpression suppresses the proliferation and promotes apoptosis of human hepatocellular carcinoma cells

Ziyou Huai, Wanying Xue, Xinxiao Jin, Shiyu Peng, Wenqiang Xu, Shujing Li, Huanfeng Hao, Yuanyuan Wang
Article Number: 157
Published online on: 14 July 2026

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Correction Open Access

[Corrigendum] VDAC upregulation and αTAT1‑mediated α‑tubulin acetylation contribute to tanespimycin‑induced apoptosis in Calu‑1 cells

Qilin Wang, Xiangguo Liu
Article Number: 156
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] Synergistic cytotoxic effects of inorganic phosphate and chemotherapeutic drugs on human osteosarcoma cells

Annamaria Spina, Luca Sorvillo, Emilio Chiosi, Antonietta Esposito, Francesca Di Maiolo, Luigi Sapio, Michele Caraglia, Silvio Naviglio
Article Number: 155
Published online on: 06 July 2026

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Article Open Access

Identification of RRM2 as a key regulator of malignant epithelial cells in gastric cancer through single‑cell transcriptomics

Xinzhen Cai, Yun He, Lili Kang, Dongli Zhou, Mengmeng Wang, Tianyu Ma
Article Number: 154
Published online on: 03 July 2026

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Article

Impact of WFDC2 on the biological functions of cervical cancer cells and the regulation of the ERK/NF‑κB signaling pathway

Yanping Zhang, Hongling Zou, Shufeng Deng, Lvling Zou, Mingzhu Xia, Limin Tao
Article Number: 153
Published online on: 01 July 2026

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Journal Cover
October-2026 Volume 56 Issue 4

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Expression of Concern Open Access

[Expression of Concern] Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways

Zhenhua Yang, Ying Liu, Changzheng Shi, Yuqin Zhang, Rongzhao Lv, Rong Zhang, Qian Wang, Yiming Wang
Article Number: 173
Published online on: 12 August 2026

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Article Open Access

OLR1 promotes cell proliferation and invasion while represses apoptosis via regulating histone H3 lysine 18 lactylation‑mediated LEMD1 in papillary thyroid cancer

Jiawei Yu, Rui Pang, Bo Liu, Lili Chen, Jiewu Zhang
Article Number: 172
Published online on: 11 August 2026

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Correction Open Access

[Corrigendum] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 171
Published online on: 10 August 2026

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Review Open Access

Polyphenol‑based interventions in breast cancer: Signaling pathways, molecular mechanisms and translational therapeutic strategies (Review)

Jingjing Zeng, Jinyan Hu, Zhiyuan Ma, Suansuan Zhu, Xiangling Lv, Lanhai Zhang, Mimi Shen, Taolang Li
Article Number: 170
Published online on: 07 August 2026

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Article Open Access

HDAC1 promotes lung adenocarcinoma progression via the nuclear accumulation of β‑catenin

Shijie Xu, Xiaolu Chang, Xiayu Wu, Fabao Wang, Jing Xiang, Chaoxiang Lin, He Zhao, Junzhe Li, Xianhua Xu
Article Number: 169
Published online on: 07 August 2026

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Retraction Open Access

[Retracted] MicroRNA‑365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3

Yonggang Zhu, Hongguang Zhao, Min Rao, Songbai Xu
Article Number: 168
Published online on: 27 July 2026

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Review Open Access

CTGF: The remodeler of the tumor immune microenvironment (Review)

Ying Zhao, Li Han, Qingyu Wu, Haiying Li, Fuhong Dai
Article Number: 167
Published online on: 24 July 2026

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Article Open Access

Anticancer effects of tangeretin associated with reactive oxygen species generation, mitochondrial dysfunction and apoptosis in CaSki cells

Seung-Hyeon Ahn, Zeeshan Ahmad Bhutta, Hwayoung Na, Hong Kyu Lee, Kyung-Chul Choi
Article Number: 166
Published online on: 24 July 2026

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Article Open Access

Stable overexpression of Nup88 enhances HeLa cell migration through independent regulation of Kif7 and Gli1

Masaki Makise, Ryota Uchimura, Ayano Shiraishi, Akihiko Kuniyasu
Article Number: 165
Published online on: 24 July 2026

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Article

TPD54 contributes to docetaxel resistance through modulation of P‑glycoprotein localization and activity in oral squamous cell carcinoma cells

Maki Nara, Yoshiki Mukudai, Masataka Watanabe, Nodoka Kindaichi, Konomi Yamada, Yuzo Abe, Toshikazu Shimane, Tatsuo Shirota, Seigo Ohba
Article Number: 164
Published online on: 24 July 2026

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