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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-June 2001 Volume 8 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-June 2001 Volume 8 Issue 3

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Article

Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer

  • Authors:
    • K. Katano
    • S. Tsujitani
    • M. Maeta
    • K. Fukuda
    • S. Oka
    • K. Hisamitsu
    • M. Ikeguchi
    • N. Kaibara

  • View Affiliations / Copyright

    Affiliations: Department of Surgery I, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan
  • Pages: 605-609
    |
    Published online on: May 1, 2001
       https://doi.org/10.3892/or.8.3.605
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Abstract

Intraoperative intrapleural (i.pl.) cisplatin (CDDP) treatment during thoracotomy was performed for esophageal cancers. Three patients underwent isotonic (308 mOsm/l) CDDP treatment. Hypotonic CDDP treatments with a 154 mOsm/l solution and a 62 mOsm/l solution were administered to 4 and 9 patients, respectively. The maximum concentrations (Cmax) of both total and filterable platinum in the plasma after injection of the hypotonic solution were significantly higher than those after injection of the isotonic solution. The area under the curve of concentration versus time (AUC) of the plasma of the 62 mOsm/l solution was significantly higher than that of the 154 mOsm/l and isotonic solution. Although higher levels of the Cmax may increase side-effects, the hypotonic condition of the i.pl. fluid and increased AUC in the plasma may escalate the accumulation of platinum in i.pl. cancer cells. These results suggest that hypotonic i.pl. CDDP is tolerable and may be useful for treatment of the incipient phase of pleural carcinomatosis and for prophylaxis of postoperative recurrence.

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Copy and paste a formatted citation
Spandidos Publications style
Katano K, Tsujitani S, Maeta M, Fukuda K, Oka S, Hisamitsu K, Ikeguchi M and Kaibara N: Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer. Oncol Rep 8: 605-609, 2001.
APA
Katano, K., Tsujitani, S., Maeta, M., Fukuda, K., Oka, S., Hisamitsu, K. ... Kaibara, N. (2001). Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer. Oncology Reports, 8, 605-609. https://doi.org/10.3892/or.8.3.605
MLA
Katano, K., Tsujitani, S., Maeta, M., Fukuda, K., Oka, S., Hisamitsu, K., Ikeguchi, M., Kaibara, N."Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer". Oncology Reports 8.3 (2001): 605-609.
Chicago
Katano, K., Tsujitani, S., Maeta, M., Fukuda, K., Oka, S., Hisamitsu, K., Ikeguchi, M., Kaibara, N."Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer". Oncology Reports 8, no. 3 (2001): 605-609. https://doi.org/10.3892/or.8.3.605
Copy and paste a formatted citation
x
Spandidos Publications style
Katano K, Tsujitani S, Maeta M, Fukuda K, Oka S, Hisamitsu K, Ikeguchi M and Kaibara N: Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer. Oncol Rep 8: 605-609, 2001.
APA
Katano, K., Tsujitani, S., Maeta, M., Fukuda, K., Oka, S., Hisamitsu, K. ... Kaibara, N. (2001). Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer. Oncology Reports, 8, 605-609. https://doi.org/10.3892/or.8.3.605
MLA
Katano, K., Tsujitani, S., Maeta, M., Fukuda, K., Oka, S., Hisamitsu, K., Ikeguchi, M., Kaibara, N."Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer". Oncology Reports 8.3 (2001): 605-609.
Chicago
Katano, K., Tsujitani, S., Maeta, M., Fukuda, K., Oka, S., Hisamitsu, K., Ikeguchi, M., Kaibara, N."Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer". Oncology Reports 8, no. 3 (2001): 605-609. https://doi.org/10.3892/or.8.3.605
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