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An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer

  • Authors:
    • Junichi Sakamoto
    • Susumu Kodaira
    • Chikuma Hamada
    • Katsuki Ito
    • Yoshihiko Maehara
    • Hiroshi Takagi
    • Keizo Sugimachi
    • Hiroaki Nakazato
    • Yasuo Ohashi

  • View Affiliations

  • Published online on: May 1, 2001     https://doi.org/10.3892/or.8.3.697
  • Pages: 697-703
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Abstract

To reappraise the benefits of the long supported chemotherapy with carmofur, a meta-analysis based on individual patient data from the three clinical trials was performed by pooling 614 patients from three trials, there is a statistically significant survival benefit (2p=0.032) and disease-free survival (DFS) benefit (2p=0.021) for carmofur; and a highly significant advantage for carmofur in DFS (2p=0.0004) and in survival (2p=0.004) in Dukes' C patients. This IPD meta-analysis strongly suggested an effect of oral carmofur in a long supported chemotherapy for curatively resected colorectal carcinoma.

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May-June 2001
Volume 8 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Sakamoto J, Kodaira S, Hamada C, Ito K, Maehara Y, Takagi H, Sugimachi K, Nakazato H and Ohashi Y: An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer. Oncol Rep 8: 697-703, 2001
APA
Sakamoto, J., Kodaira, S., Hamada, C., Ito, K., Maehara, Y., Takagi, H. ... Ohashi, Y. (2001). An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer. Oncology Reports, 8, 697-703. https://doi.org/10.3892/or.8.3.697
MLA
Sakamoto, J., Kodaira, S., Hamada, C., Ito, K., Maehara, Y., Takagi, H., Sugimachi, K., Nakazato, H., Ohashi, Y."An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer". Oncology Reports 8.3 (2001): 697-703.
Chicago
Sakamoto, J., Kodaira, S., Hamada, C., Ito, K., Maehara, Y., Takagi, H., Sugimachi, K., Nakazato, H., Ohashi, Y."An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer". Oncology Reports 8, no. 3 (2001): 697-703. https://doi.org/10.3892/or.8.3.697