Absence of therapeutically relevant c-erbB-2 expression in human hepatocellular carcinomas

  • Authors:
    • Wilhelm Prange
    • Peter Schirmacher
  • View Affiliations

  • Published online on: July 1, 2001     https://doi.org/10.3892/or.8.4.727
  • Pages: 727-730
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Abstract

c-erbB-2 (Her-2/neu) represents a well established prognostic marker and therapeutic target in several human tumor types, especially breast cancer. Its potential role in hepatocellular carcinoma (HCC) has not yet been characterized. Using standardized immunohistochemical procedures, we have analyzed the c-erbB-2 expression in a representative panel of human HCCs. Our data demonstrate the absence of significant membranous expression or cytoplasmic overexpression. Thus c-erbB-2 is neither a prognostic marker nor a relevant therapeutic target in human HCCs.

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July-August 2001
Volume 8 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Prange W and Prange W: Absence of therapeutically relevant c-erbB-2 expression in human hepatocellular carcinomas. Oncol Rep 8: 727-730, 2001
APA
Prange, W., & Prange, W. (2001). Absence of therapeutically relevant c-erbB-2 expression in human hepatocellular carcinomas. Oncology Reports, 8, 727-730. https://doi.org/10.3892/or.8.4.727
MLA
Prange, W., Schirmacher, P."Absence of therapeutically relevant c-erbB-2 expression in human hepatocellular carcinomas". Oncology Reports 8.4 (2001): 727-730.
Chicago
Prange, W., Schirmacher, P."Absence of therapeutically relevant c-erbB-2 expression in human hepatocellular carcinomas". Oncology Reports 8, no. 4 (2001): 727-730. https://doi.org/10.3892/or.8.4.727