Thymidine phosphorylase expression and effect of doxifluridine: A phase II study

  • Authors:
    • Sotaro Sadahiro
    • Yoshimasa Otani
    • Kazumitsu Oya
    • Hideyuki Ike
    • Hiroshi Shimada
    • Susumu Yamaguchi
    • Yoshiki Hiki
    • Hiroshi Fujita
    • Toshio Mitomi
  • View Affiliations

  • Published online on: July 1, 2001     https://doi.org/10.3892/or.8.4.753
  • Pages: 753-758
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Abstract

Doxifluridine (5'-DFUR), an active intermediate metabolite of capecitabine, is converted to 5-fluorouracil by thymidine phosphorylase (TP). We used immunohistochemical staining to investigate the relation between TP expression and 5'-DFUR effects in 40 patients with advanced/recurrent lung metastases from colorectal cancer. Cox regression analysis suggested that TP-positive cancer cells (risk ratio 3.72), were independent factors in survival whereas factors in progression-free survival were TP-positive cancer cells (2.93), and TP-positive stromal cells (0.24). It is suggested that TP expression in cancer cells and in stromal cells are opposite prognostic factors in patients treated with 5'-DFUR.

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July-August 2001
Volume 8 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sadahiro S, Otani Y, Oya K, Ike H, Shimada H, Yamaguchi S, Hiki Y, Fujita H and Mitomi T: Thymidine phosphorylase expression and effect of doxifluridine: A phase II study. Oncol Rep 8: 753-758, 2001
APA
Sadahiro, S., Otani, Y., Oya, K., Ike, H., Shimada, H., Yamaguchi, S. ... Mitomi, T. (2001). Thymidine phosphorylase expression and effect of doxifluridine: A phase II study. Oncology Reports, 8, 753-758. https://doi.org/10.3892/or.8.4.753
MLA
Sadahiro, S., Otani, Y., Oya, K., Ike, H., Shimada, H., Yamaguchi, S., Hiki, Y., Fujita, H., Mitomi, T."Thymidine phosphorylase expression and effect of doxifluridine: A phase II study". Oncology Reports 8.4 (2001): 753-758.
Chicago
Sadahiro, S., Otani, Y., Oya, K., Ike, H., Shimada, H., Yamaguchi, S., Hiki, Y., Fujita, H., Mitomi, T."Thymidine phosphorylase expression and effect of doxifluridine: A phase II study". Oncology Reports 8, no. 4 (2001): 753-758. https://doi.org/10.3892/or.8.4.753