Use of c-myb antisense oligonucleotides to increase the sensitivity of human colon cancer cells to cisplatin

  • Authors:
    • T. Funato
    • J. Satou
    • K. Kozawa
    • S. Fujimaki
    • T. Miura
    • M. Kaku
  • View Affiliations

  • Published online on: July 1, 2001     https://doi.org/10.3892/or.8.4.807
  • Pages: 807-810
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Abstract

Human colon cancer SW480DDP and SW620DDP cells resistant to cisplatin exhibited stronger c-myb gene expression than the parent SW480 and SW620 cells. However, cell growth rates in the cisplatin-resistant cell lines remained similar to those of the parent cells. Antisense oligonucleotides to c-myb inhibited c-myb expression and induced increased sensitivity to cisplatin in SW480DDP and SW620DDP cells, but this did not occur with the control sense oligonucleotides. In contrast, the parent cell lines were not affected by antisense oligonucleotides to c-myb. These results indicate that the c-myb gene in human colon cancer is one of the factors related to cisplatin resistance, and support the need to develop anti-cancer therapeutics based on oncogene-targeted antisense oligonucleotide technology.

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July-August 2001
Volume 8 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Funato T, Satou J, Kozawa K, Fujimaki S, Miura T and Kaku M: Use of c-myb antisense oligonucleotides to increase the sensitivity of human colon cancer cells to cisplatin. Oncol Rep 8: 807-810, 2001
APA
Funato, T., Satou, J., Kozawa, K., Fujimaki, S., Miura, T., & Kaku, M. (2001). Use of c-myb antisense oligonucleotides to increase the sensitivity of human colon cancer cells to cisplatin. Oncology Reports, 8, 807-810. https://doi.org/10.3892/or.8.4.807
MLA
Funato, T., Satou, J., Kozawa, K., Fujimaki, S., Miura, T., Kaku, M."Use of c-myb antisense oligonucleotides to increase the sensitivity of human colon cancer cells to cisplatin". Oncology Reports 8.4 (2001): 807-810.
Chicago
Funato, T., Satou, J., Kozawa, K., Fujimaki, S., Miura, T., Kaku, M."Use of c-myb antisense oligonucleotides to increase the sensitivity of human colon cancer cells to cisplatin". Oncology Reports 8, no. 4 (2001): 807-810. https://doi.org/10.3892/or.8.4.807