Plasma VEGF concentration can predict the tumor angiogenic capacity in non-small cell lung cancer

  • Authors:
    • Masaya Tamura
    • Yasuhiko Ohta
    • Takeshi Kajita
    • Keiichi Kimura
    • Tetsuhiko Go
    • Makoto Oda
    • Hisoyuhi Nakamura
    • Goh Watanabe
  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/or.8.5.1097
  • Pages: 1097-1102
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Abstract

We assessed the clinical utility of circulating angiogenic factors as a predictor for tumor angiogenesis in primary lung cancer. Circulating vascular endothelial growth factor (VEGF) and intratumoral VEGF were assessed by enzyme-linked immuno-sorbent assay (ELISA). There was a significant increase in the mean value of both plasma and serum VEGF concentration in primary lung cancer patients (n=97) compared to those of healthy controls (n=59). There was a significant correlation between plasma VEGF levels and microvessel density (MVD), and also between plasma VEGF and intratumoral VEGF levels. Plasma VEGF in patients with lung cancer appears to be a useful indicator of tumor angiogenesis.

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September-October 2001
Volume 8 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Tamura M, Ohta Y, Kajita T, Kimura K, Go T, Oda M, Nakamura H and Watanabe G: Plasma VEGF concentration can predict the tumor angiogenic capacity in non-small cell lung cancer. Oncol Rep 8: 1097-1102, 2001.
APA
Tamura, M., Ohta, Y., Kajita, T., Kimura, K., Go, T., Oda, M. ... Watanabe, G. (2001). Plasma VEGF concentration can predict the tumor angiogenic capacity in non-small cell lung cancer. Oncology Reports, 8, 1097-1102. https://doi.org/10.3892/or.8.5.1097
MLA
Tamura, M., Ohta, Y., Kajita, T., Kimura, K., Go, T., Oda, M., Nakamura, H., Watanabe, G."Plasma VEGF concentration can predict the tumor angiogenic capacity in non-small cell lung cancer". Oncology Reports 8.5 (2001): 1097-1102.
Chicago
Tamura, M., Ohta, Y., Kajita, T., Kimura, K., Go, T., Oda, M., Nakamura, H., Watanabe, G."Plasma VEGF concentration can predict the tumor angiogenic capacity in non-small cell lung cancer". Oncology Reports 8, no. 5 (2001): 1097-1102. https://doi.org/10.3892/or.8.5.1097