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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2001 Volume 8 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Muscle wasting after radiotherapy in young and adult rats

  • Authors:
    • C. C.M. Persons
    • A. F. Hermens
    • N. A.P. Franken
    • J. Wondergem

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oncology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
  • Pages: 1117-1122
    |
    Published online on: September 1, 2001
       https://doi.org/10.3892/or.8.5.1117
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Abstract

The impact of late muscular injury after radiotherapy on the well being of patients, particularly those treated at a relatively young age, is often underestimated. To extend the present knowledge, a detailed comparative study of the radiation response of skeletal muscles was performed. The hind limb of rats was irradiated at the age of 30-60 days (young), at ≈200 days (adult) or at the age of >360 days (old), with single doses ranging from 15-60 Gy. Muscular wet weight, volume and tibia length was followed up to 12 months post-treatment. Radiation treatment resulted in muscular wasting, which was more severe at higher doses. The radiation response depended strongly on the age of the animal at the time of treatment. Radiation induced muscle wasting and stunted tibia growth were more prominent in young animals than in adult or in old rats. ED50 values based on normalized wet weight were 12.5 (11.5-13.6) Gy for young animals and 22.5 (21.8-23.3) Gy for adult animals. The gastrocnemius muscle of young animals appears to be more radiosensitive than the gastrocnemius muscle of adult or old animals. Furthermore, in young animals, severe wasting of the muscles may already occur after relative low radiation doses (single dose of 15 Gy).

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Copy and paste a formatted citation
Spandidos Publications style
Persons CC, Hermens AF, Franken NA and Wondergem J: Muscle wasting after radiotherapy in young and adult rats. Oncol Rep 8: 1117-1122, 2001.
APA
Persons, C.C., Hermens, A.F., Franken, N.A., & Wondergem, J. (2001). Muscle wasting after radiotherapy in young and adult rats. Oncology Reports, 8, 1117-1122. https://doi.org/10.3892/or.8.5.1117
MLA
Persons, C. C., Hermens, A. F., Franken, N. A., Wondergem, J."Muscle wasting after radiotherapy in young and adult rats". Oncology Reports 8.5 (2001): 1117-1122.
Chicago
Persons, C. C., Hermens, A. F., Franken, N. A., Wondergem, J."Muscle wasting after radiotherapy in young and adult rats". Oncology Reports 8, no. 5 (2001): 1117-1122. https://doi.org/10.3892/or.8.5.1117
Copy and paste a formatted citation
x
Spandidos Publications style
Persons CC, Hermens AF, Franken NA and Wondergem J: Muscle wasting after radiotherapy in young and adult rats. Oncol Rep 8: 1117-1122, 2001.
APA
Persons, C.C., Hermens, A.F., Franken, N.A., & Wondergem, J. (2001). Muscle wasting after radiotherapy in young and adult rats. Oncology Reports, 8, 1117-1122. https://doi.org/10.3892/or.8.5.1117
MLA
Persons, C. C., Hermens, A. F., Franken, N. A., Wondergem, J."Muscle wasting after radiotherapy in young and adult rats". Oncology Reports 8.5 (2001): 1117-1122.
Chicago
Persons, C. C., Hermens, A. F., Franken, N. A., Wondergem, J."Muscle wasting after radiotherapy in young and adult rats". Oncology Reports 8, no. 5 (2001): 1117-1122. https://doi.org/10.3892/or.8.5.1117
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