Loss of heterozygosity of nucleotide excision repair factors in sporadic oral squamous cell carcinoma using microdissected tissue

  • Authors:
    • Hitoshi Miyashita
    • Shiro Mori
    • Naoko Tanda
    • Kentaro Nakayama
    • Atsuko Kanzaki
    • Atushi Sato
    • Hidehiro Morikawa
    • Katutoshi Motegi
    • Yuji Takebayashi
    • Manabu Fukumoto
  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/or.8.5.1133
  • Pages: 1133-1138
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The deficiencies of nucleotide excision repair (NER) factors are involved in rare genetic diseases such as xeroderma pigmentosum (XP) with increased risk of developing cancer on sun-exposed areas of the skin. However, the abnormality of NER factors in human sporadic carcinoma remains unclear. Loss of heterozygosity (LOH) analysis, using the microdissected tissues, for the XPA, XPB, XPC, XPD, XPE, XPF, XPG and the transcription-coupled repair factor, Cockayne syndrome B (CSB) revealed that NER factors were abnormal in 30.0% (3/10 cases) of oral squamous cell carcinomas. Furthermore, 10.0% of oral carcinomas exhibited LOH for NER factors without LOH for tumor suppressor genes such as p53, FHIT, APC, BRCA1, BRCA2 and DCC. These observations raise the possibility that alterations of NER factors may be involved in carcinogenesis in human oral squamous cell carcinoma.

Related Articles

Journal Cover

September-October 2001
Volume 8 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Miyashita H, Mori S, Tanda N, Nakayama K, Kanzaki A, Sato A, Morikawa H, Motegi K, Takebayashi Y, Fukumoto M, Fukumoto M, et al: Loss of heterozygosity of nucleotide excision repair factors in sporadic oral squamous cell carcinoma using microdissected tissue. Oncol Rep 8: 1133-1138, 2001.
APA
Miyashita, H., Mori, S., Tanda, N., Nakayama, K., Kanzaki, A., Sato, A. ... Fukumoto, M. (2001). Loss of heterozygosity of nucleotide excision repair factors in sporadic oral squamous cell carcinoma using microdissected tissue. Oncology Reports, 8, 1133-1138. https://doi.org/10.3892/or.8.5.1133
MLA
Miyashita, H., Mori, S., Tanda, N., Nakayama, K., Kanzaki, A., Sato, A., Morikawa, H., Motegi, K., Takebayashi, Y., Fukumoto, M."Loss of heterozygosity of nucleotide excision repair factors in sporadic oral squamous cell carcinoma using microdissected tissue". Oncology Reports 8.5 (2001): 1133-1138.
Chicago
Miyashita, H., Mori, S., Tanda, N., Nakayama, K., Kanzaki, A., Sato, A., Morikawa, H., Motegi, K., Takebayashi, Y., Fukumoto, M."Loss of heterozygosity of nucleotide excision repair factors in sporadic oral squamous cell carcinoma using microdissected tissue". Oncology Reports 8, no. 5 (2001): 1133-1138. https://doi.org/10.3892/or.8.5.1133