Immune reactivity during the growth of a murine lung adenocarcinoma: Evaluation of paraneoplastic syndrome development

  • Authors:
    • Miriam J. Diament
    • Corina Garcia
    • Mariano Parma
    • Nelida Mondelo
    • Isabel Stillitani
    • Slobodanka Klein
  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/or.8.5.1165
  • Pages: 1165-1170
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Abstract

The purpose of this study was to investigate if specific immune responses were present in mice bearing a lung adenocarcinoma that presents paraneoplastic syndromes during tumor evolution. Leukocytosis, mainly due to polymorphonuclear leukocytes, was found from day 15 of tumor growth. Delayed type hypersensitivity response and increased interleukin-6 (IL-6) serum levels were observed along tumor growth. Concomitant immunity, specific rejection of a second inoculum and in vitro specific cytotoxicity occurred at 20 days of implant. In advanced stages of tumor evolution impaired cytotoxicity, accompanied by a great increase of IL-6 in serum, were observed. Role of polymorphonuclear leukocytes and IL-6 overproduction as responsible for immune dysregulation and paraneoplastic syndromes are discussed.

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September-October 2001
Volume 8 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Diament MJ, Garcia C, Parma M, Mondelo N, Stillitani I and Klein S: Immune reactivity during the growth of a murine lung adenocarcinoma: Evaluation of paraneoplastic syndrome development. Oncol Rep 8: 1165-1170, 2001
APA
Diament, M.J., Garcia, C., Parma, M., Mondelo, N., Stillitani, I., & Klein, S. (2001). Immune reactivity during the growth of a murine lung adenocarcinoma: Evaluation of paraneoplastic syndrome development. Oncology Reports, 8, 1165-1170. https://doi.org/10.3892/or.8.5.1165
MLA
Diament, M. J., Garcia, C., Parma, M., Mondelo, N., Stillitani, I., Klein, S."Immune reactivity during the growth of a murine lung adenocarcinoma: Evaluation of paraneoplastic syndrome development". Oncology Reports 8.5 (2001): 1165-1170.
Chicago
Diament, M. J., Garcia, C., Parma, M., Mondelo, N., Stillitani, I., Klein, S."Immune reactivity during the growth of a murine lung adenocarcinoma: Evaluation of paraneoplastic syndrome development". Oncology Reports 8, no. 5 (2001): 1165-1170. https://doi.org/10.3892/or.8.5.1165