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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
September-October 2001 Volume 8 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2001 Volume 8 Issue 5

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Article

Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8

  • Authors:
    • Keiji Inoue
    • Christopher G. Wood
    • Joel W. Slaton
    • Takashi Karashima
    • Paul Sweeney
    • Colin P.N. Dinney

  • View Affiliations / Copyright

    Affiliations: Department of Cancer Biology, The University of Texas M.D Anderson Cancer Center, Houston, TX 77030, USA
  • Pages: 955-964
    |
    Published online on: September 1, 2001
       https://doi.org/10.3892/or.8.5.955
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Abstract

We previously demonstrated the importance of interleukin-8 (IL-8) as a mediator of angiogenesis, tumorigenicity, and metastasis of transitional cell carcinoma (TCC) of the bladder. In the present study, we evaluated the feasibility of adenoviral mediated antisense IL-8 gene transfer (Ad IL-8-AS) as therapy for established TCC. In vitro, Ad IL-8-AS inhibited endothelial cell proliferation and enhanced endothelial cell apoptosis. The highly metastatic human TCC cell line 253J B-VR was implanted into the subcutis of athymic nude mice, and intralesional therapy with Ad IL-8-AS commenced when the tumors reached a diameter between 5 and 7 mm. Tumor growth was significantly inhibited compared with therapy in controls (saline and β-galactosidase adenovirus). Ad IL-8-AS therapy decreased the in vivo expression of IL-8 and matrix metalloproteinase type 9 (MMP-9), reduced microvessel density, and enhanced endothelial cell apoptosis. These results indicate that Ad IL-8-AS therapy targets both tumor cells and host endothelial cells resulting in endothelial cell apoptosis and significant inhibition of tumor growth.

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Copy and paste a formatted citation
Spandidos Publications style
Inoue K, Wood CG, Slaton JW, Karashima T, Sweeney P and Dinney CP: Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8. Oncol Rep 8: 955-964, 2001.
APA
Inoue, K., Wood, C.G., Slaton, J.W., Karashima, T., Sweeney, P., & Dinney, C.P. (2001). Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8. Oncology Reports, 8, 955-964. https://doi.org/10.3892/or.8.5.955
MLA
Inoue, K., Wood, C. G., Slaton, J. W., Karashima, T., Sweeney, P., Dinney, C. P."Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8". Oncology Reports 8.5 (2001): 955-964.
Chicago
Inoue, K., Wood, C. G., Slaton, J. W., Karashima, T., Sweeney, P., Dinney, C. P."Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8". Oncology Reports 8, no. 5 (2001): 955-964. https://doi.org/10.3892/or.8.5.955
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue K, Wood CG, Slaton JW, Karashima T, Sweeney P and Dinney CP: Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8. Oncol Rep 8: 955-964, 2001.
APA
Inoue, K., Wood, C.G., Slaton, J.W., Karashima, T., Sweeney, P., & Dinney, C.P. (2001). Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8. Oncology Reports, 8, 955-964. https://doi.org/10.3892/or.8.5.955
MLA
Inoue, K., Wood, C. G., Slaton, J. W., Karashima, T., Sweeney, P., Dinney, C. P."Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8". Oncology Reports 8.5 (2001): 955-964.
Chicago
Inoue, K., Wood, C. G., Slaton, J. W., Karashima, T., Sweeney, P., Dinney, C. P."Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8". Oncology Reports 8, no. 5 (2001): 955-964. https://doi.org/10.3892/or.8.5.955
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