Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer

  • Authors:
    • J. Feng
    • F. Hua
    • R. Shuo
    • G. Chongfeng
    • X. Huimian
    • T. Nakajima
    • W. Subao
    • N. Tsuchida
  • View Affiliations

  • Published online on: November 1, 2001     https://doi.org/10.3892/or.8.6.1409
  • Pages: 1409-1413
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Abstract

We analyzed H-ras protein expression in 38 human colon cancers and the paired normal tissues. H-ras levels were significantly higher in the malignant tumor (average 0.19±0.27) than in its normal adjacent tissues (average 0.06±0.15) (p<0.05). The H-ras protein expressed in colon carcinomas contained activated form of H-ras without mutation, based on the findings obtained by RBD-binding (ras binding domain of Raf protein) assay and PCR-SSCP analysis. In addition, we found that H-ras expression was higher in female patients than male, and in cancers with distant metastasis compared to those with non-distant metastasis. Good correlation between H-ras expression levels and those of the upstream and downstream signaling proteins of EGFR, MEK and ERK was found, suggesting that H-ras may play a significant role in carcinogensis of colorectal cancer.

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November-December 2001
Volume 8 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Feng J, Hua F, Shuo R, Chongfeng G, Huimian X, Nakajima T, Subao W and Tsuchida N: Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer. Oncol Rep 8: 1409-1413, 2001
APA
Feng, J., Hua, F., Shuo, R., Chongfeng, G., Huimian, X., Nakajima, T. ... Tsuchida, N. (2001). Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer. Oncology Reports, 8, 1409-1413. https://doi.org/10.3892/or.8.6.1409
MLA
Feng, J., Hua, F., Shuo, R., Chongfeng, G., Huimian, X., Nakajima, T., Subao, W., Tsuchida, N."Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer". Oncology Reports 8.6 (2001): 1409-1413.
Chicago
Feng, J., Hua, F., Shuo, R., Chongfeng, G., Huimian, X., Nakajima, T., Subao, W., Tsuchida, N."Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer". Oncology Reports 8, no. 6 (2001): 1409-1413. https://doi.org/10.3892/or.8.6.1409