K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix

  • Authors:
    • Prokopis Prokopakis
    • George Sourvinos
    • Yvoni Koumantaki
    • Eugenios Koumantakis
    • Demetrios A. Spandidos
  • View Affiliations

  • Published online on: January 1, 2002     https://doi.org/10.3892/or.9.1.129
  • Pages: 129-133
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Abstract

Activation of ras genes and human papilloma virus (HPV) infection have been extensively described in cervical carcinomas while information concerning their implication in premalignant lesions of the cervix is limited. We investigated the incidence of K-ras codon 12 point mutations and HPV infection in cases of cervicitis and cervical intraepithelial neoplasias (CIN). Forty-seven cases of women with cervicitis or CIN were examined for the presence of K-ras mutations and HPV infection using PCR-RFLP methodology. Furthermore, HPV typing was carried out in HPV positive samples by multiplex PCR. K-ras mutations were detected in 7/47 cases (15%) while HPV genome was found in 17/47 cases (36%). HPV typing revealed HPV-18 at a higher rate than HPV-16 (71% vs 29%). No statistically significant association was observed between the presence of K-ras mutations, HPV infection and clinical parameters or smoking-alcohol habits. Our results suggest that mutational activation of K-ras gene is implicated in the development of premalignant cervical lesions and HPV infection may be an important step in the development of premalignant cervical lesions.

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January-February 2002
Volume 9 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Prokopakis P, Sourvinos G, Koumantaki Y, Koumantakis E and Spandidos DA: K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix. Oncol Rep 9: 129-133, 2002
APA
Prokopakis, P., Sourvinos, G., Koumantaki, Y., Koumantakis, E., & Spandidos, D.A. (2002). K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix. Oncology Reports, 9, 129-133. https://doi.org/10.3892/or.9.1.129
MLA
Prokopakis, P., Sourvinos, G., Koumantaki, Y., Koumantakis, E., Spandidos, D. A."K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix". Oncology Reports 9.1 (2002): 129-133.
Chicago
Prokopakis, P., Sourvinos, G., Koumantaki, Y., Koumantakis, E., Spandidos, D. A."K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix". Oncology Reports 9, no. 1 (2002): 129-133. https://doi.org/10.3892/or.9.1.129