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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January-February 2002 Volume 9 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Differential TAG-72 epitope expression in breast cancer and lymph node metastases: a marker of a more aggressive phenotype

  • Authors:
    • Annamaria Galietta
    • Claudia Pizzi
    • Guido Pettinato
    • Gennaro Limite
    • Alessandro Sgambato
    • Maria Lamberti
    • Raffaella Muraro
    • Cesare Formisano
    • Matilde Pensabene
    • Angelo Raffaele Bianco
    • Renato Mariani-Costantini
    • Alma Contegiacomo
  • View Affiliations / Copyright

    Affiliations: Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Universita di Napoli <Federico II>, Naples, Italy
  • Pages: 135-140
    |
    Published online on: January 1, 2002
       https://doi.org/10.3892/or.9.1.135
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Abstract

We analysed the differential expression pattern of the three distinct TAG-72 carbohydrate epitopes detected by monoclonal antibodies (MAbs) B72.3, CC83 and CC49 in a consecutive series of 114 patients with primary breast cancer and in 39 synchronous lymph node metastases. B72.3, CC83 and CC49 were expressed in respectively 81 (71%), 68 (60%) and 96 (84%) of the 114 cases. Interestingly, MAb B72.3 was significantly expressed in a subgroup of patients characterised by larger tumour size (p=0.013), lymph node metastasis (p=0.0002), high histopathological grade (p=0.006), high cell kinetics (p=0.04) and advanced clinical stage (p=0.0019). In 20 (51%) of the 39 pairs of matched primary breast cancers and synchronous lymph node metastases, TAG-72 was expressed in the tumour but not in the corresponding metastatic lymph node; tumours with TAG-72-negative lymph nodes appeared to be clinicopathologically more aggressive. CC49, the most immunoreactive and widely used MAb, was not detected in 34% of the metastases of expressing primary tumours. All three MAbs were found in a significantly lower per cent of synchronous metastases with respect to primary tumours (p<0.001).

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Copy and paste a formatted citation
Spandidos Publications style
Galietta A, Pizzi C, Pettinato G, Limite G, Sgambato A, Lamberti M, Muraro R, Formisano C, Pensabene M, Bianco AR, Bianco AR, et al: Differential TAG-72 epitope expression in breast cancer and lymph node metastases: a marker of a more aggressive phenotype. Oncol Rep 9: 135-140, 2002.
APA
Galietta, A., Pizzi, C., Pettinato, G., Limite, G., Sgambato, A., Lamberti, M. ... Contegiacomo, A. (2002). Differential TAG-72 epitope expression in breast cancer and lymph node metastases: a marker of a more aggressive phenotype. Oncology Reports, 9, 135-140. https://doi.org/10.3892/or.9.1.135
MLA
Galietta, A., Pizzi, C., Pettinato, G., Limite, G., Sgambato, A., Lamberti, M., Muraro, R., Formisano, C., Pensabene, M., Bianco, A. R., Mariani-Costantini, R., Contegiacomo, A."Differential TAG-72 epitope expression in breast cancer and lymph node metastases: a marker of a more aggressive phenotype". Oncology Reports 9.1 (2002): 135-140.
Chicago
Galietta, A., Pizzi, C., Pettinato, G., Limite, G., Sgambato, A., Lamberti, M., Muraro, R., Formisano, C., Pensabene, M., Bianco, A. R., Mariani-Costantini, R., Contegiacomo, A."Differential TAG-72 epitope expression in breast cancer and lymph node metastases: a marker of a more aggressive phenotype". Oncology Reports 9, no. 1 (2002): 135-140. https://doi.org/10.3892/or.9.1.135
Copy and paste a formatted citation
x
Spandidos Publications style
Galietta A, Pizzi C, Pettinato G, Limite G, Sgambato A, Lamberti M, Muraro R, Formisano C, Pensabene M, Bianco AR, Bianco AR, et al: Differential TAG-72 epitope expression in breast cancer and lymph node metastases: a marker of a more aggressive phenotype. Oncol Rep 9: 135-140, 2002.
APA
Galietta, A., Pizzi, C., Pettinato, G., Limite, G., Sgambato, A., Lamberti, M. ... Contegiacomo, A. (2002). Differential TAG-72 epitope expression in breast cancer and lymph node metastases: a marker of a more aggressive phenotype. Oncology Reports, 9, 135-140. https://doi.org/10.3892/or.9.1.135
MLA
Galietta, A., Pizzi, C., Pettinato, G., Limite, G., Sgambato, A., Lamberti, M., Muraro, R., Formisano, C., Pensabene, M., Bianco, A. R., Mariani-Costantini, R., Contegiacomo, A."Differential TAG-72 epitope expression in breast cancer and lymph node metastases: a marker of a more aggressive phenotype". Oncology Reports 9.1 (2002): 135-140.
Chicago
Galietta, A., Pizzi, C., Pettinato, G., Limite, G., Sgambato, A., Lamberti, M., Muraro, R., Formisano, C., Pensabene, M., Bianco, A. R., Mariani-Costantini, R., Contegiacomo, A."Differential TAG-72 epitope expression in breast cancer and lymph node metastases: a marker of a more aggressive phenotype". Oncology Reports 9, no. 1 (2002): 135-140. https://doi.org/10.3892/or.9.1.135
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