5-FU improves p27-related poor prognosis in patients with Astler-Coller B2-C colorectal carcinoma

  • Authors:
    • Minako Kobayashi
    • Taizo Shiraishi
    • Hitoshi Tonouchi
    • Chikao Miki
    • Masato Kusunoki
  • View Affiliations

  • Published online on: January 1, 2002     https://doi.org/10.3892/or.9.1.29
  • Pages: 29-33
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Abstract

p27kip1 induces cell cycle arrest at the G1-S transition. To investigate the effect of UFT on the prognosis of colorectal cancer with respect to p27kip1 expression, survival curves of patients with p27kip1 overexpression (group A) and without p27kip1 expression (group B) were evaluated following chemotherapy using UFT (tegafur and uracil). Although there was no significant overall survival difference between group A and B patients, the patients without p27kip1 expression had a significantly lower survival rate when they did not receive UFT treatment. UFT, 5-FU masked compound may improve the p27-related poor prognosis in colorectal cancer patients.

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January-February 2002
Volume 9 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kobayashi M, Shiraishi T, Tonouchi H, Miki C and Kusunoki M: 5-FU improves p27-related poor prognosis in patients with Astler-Coller B2-C colorectal carcinoma. Oncol Rep 9: 29-33, 2002
APA
Kobayashi, M., Shiraishi, T., Tonouchi, H., Miki, C., & Kusunoki, M. (2002). 5-FU improves p27-related poor prognosis in patients with Astler-Coller B2-C colorectal carcinoma. Oncology Reports, 9, 29-33. https://doi.org/10.3892/or.9.1.29
MLA
Kobayashi, M., Shiraishi, T., Tonouchi, H., Miki, C., Kusunoki, M."5-FU improves p27-related poor prognosis in patients with Astler-Coller B2-C colorectal carcinoma". Oncology Reports 9.1 (2002): 29-33.
Chicago
Kobayashi, M., Shiraishi, T., Tonouchi, H., Miki, C., Kusunoki, M."5-FU improves p27-related poor prognosis in patients with Astler-Coller B2-C colorectal carcinoma". Oncology Reports 9, no. 1 (2002): 29-33. https://doi.org/10.3892/or.9.1.29