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Effect of wortmannin on the suppression of thermotolerance in tsAF8 cells

  • Authors:
    • K. Shibuya
    • S. Kawasaki
    • M. Kuroda
    • M. Takemoto
    • J.-I. Asaumi
    • Y. Hiraki

  • View Affiliations

  • Published online on: January 1, 2002     https://doi.org/10.3892/or.9.1.81
  • Pages: 81-84
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Abstract

Phosphatidylinositol 3 kinases (PI-3 kinases) play a crucial role in the inositol phospholipid signaling pathway. The effect of wortmannin, an inhibitor of PI-3 kinases, on the suppression of thermotolerance development was investigated in the temperature-sensitive cell line tsAF8. When wortmannin was added immediately after the preheating, the thermotolerance was suppressed, with this suppression being dose-dependent from 0.01 to 0.1 μM, but not dose-dependent from 0.1 to 20 μM. Our results suggest that PI-3 kinases might play an important role in thermotolerance development in tsAF8 cells.

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January-February 2002
Volume 9 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Shibuya K, Kawasaki S, Kuroda M, Takemoto M, Asaumi J and Hiraki Y: Effect of wortmannin on the suppression of thermotolerance in tsAF8 cells. Oncol Rep 9: 81-84, 2002
APA
Shibuya, K., Kawasaki, S., Kuroda, M., Takemoto, M., Asaumi, J., & Hiraki, Y. (2002). Effect of wortmannin on the suppression of thermotolerance in tsAF8 cells. Oncology Reports, 9, 81-84. https://doi.org/10.3892/or.9.1.81
MLA
Shibuya, K., Kawasaki, S., Kuroda, M., Takemoto, M., Asaumi, J., Hiraki, Y."Effect of wortmannin on the suppression of thermotolerance in tsAF8 cells". Oncology Reports 9.1 (2002): 81-84.
Chicago
Shibuya, K., Kawasaki, S., Kuroda, M., Takemoto, M., Asaumi, J., Hiraki, Y."Effect of wortmannin on the suppression of thermotolerance in tsAF8 cells". Oncology Reports 9, no. 1 (2002): 81-84. https://doi.org/10.3892/or.9.1.81