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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
March-April 2002 Volume 9 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March-April 2002 Volume 9 Issue 2

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Article

Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis

  • Authors:
    • Sharon Marsh
    • Judith A. McKay
    • Stephanie Curran
    • G. I. Murray
    • James Cassidy
    • Howard L. McLeod

  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
  • Pages: 231-234
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/or.9.2.231
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Abstract

Analysis of tumour markers is helping to predict individual patient response to chemotherapy. However, the difficulties in obtaining metastatic disease samples has led to a reliance on assessment of primary tumour, with little data on its predictive ability. This study assessed thymidylate synthase (TS), a target for the commonly used drug 5FU, in 42 paired primary colorectal tumour and lymph node metastasis. High TS staining was seen in 63% of primary colon tumour cells and 81% of the secondary lymph node. Primary tumour did not have significant predictive power for secondary tumour samples (κ=0.125; p=0.38). There was no significant relationship between TS staining and expression of G1/S cell cycle proteins p21, p27, p53, cyclin D1, proliferating cell nuclear antigen (PCNA) and retinoblastoma protein (Rb) (p>0.05 in all cases). Discordance in TS protein levels between primary and secondary tumours demonstrates the danger of predicting outcome after chemotherapy in metastatic colorectal cancer from the primary tumour.

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Copy and paste a formatted citation
Spandidos Publications style
Marsh S, McKay JA, Curran S, Murray GI, Cassidy J and McLeod HL: Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis. Oncol Rep 9: 231-234, 2002.
APA
Marsh, S., McKay, J.A., Curran, S., Murray, G.I., Cassidy, J., & McLeod, H.L. (2002). Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis. Oncology Reports, 9, 231-234. https://doi.org/10.3892/or.9.2.231
MLA
Marsh, S., McKay, J. A., Curran, S., Murray, G. I., Cassidy, J., McLeod, H. L."Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis". Oncology Reports 9.2 (2002): 231-234.
Chicago
Marsh, S., McKay, J. A., Curran, S., Murray, G. I., Cassidy, J., McLeod, H. L."Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis". Oncology Reports 9, no. 2 (2002): 231-234. https://doi.org/10.3892/or.9.2.231
Copy and paste a formatted citation
x
Spandidos Publications style
Marsh S, McKay JA, Curran S, Murray GI, Cassidy J and McLeod HL: Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis. Oncol Rep 9: 231-234, 2002.
APA
Marsh, S., McKay, J.A., Curran, S., Murray, G.I., Cassidy, J., & McLeod, H.L. (2002). Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis. Oncology Reports, 9, 231-234. https://doi.org/10.3892/or.9.2.231
MLA
Marsh, S., McKay, J. A., Curran, S., Murray, G. I., Cassidy, J., McLeod, H. L."Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis". Oncology Reports 9.2 (2002): 231-234.
Chicago
Marsh, S., McKay, J. A., Curran, S., Murray, G. I., Cassidy, J., McLeod, H. L."Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis". Oncology Reports 9, no. 2 (2002): 231-234. https://doi.org/10.3892/or.9.2.231
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