Clinical significance of p53, MDM2 and bcl-2 expression in transitional cell carcinoma of the bladder

  • Authors:
    • T. Uchida
    • S. Minei
    • J.-P. Gao
    • C. Wang
    • T. Satoh
    • S. Baba
  • View Affiliations

  • Published online on: March 1, 2002     https://doi.org/10.3892/or.9.2.253
  • Pages: 253-259
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Abstract

We investigated the prognostic and predictive relevance of p53, MDM2, and bcl-2 protein expression in patients with transitional cell carcinoma (TCC) of the bladder. The expression of p53, MDM2 and bcl-2 protein was studied by immunohistochemical methods in paraffin-embedded specimens from 119 patients whose clinicopathologic data confirmed TCC of the bladder. Multivariate analyses of prognostic factors were performed, and correlations with classical clinicopathologic parameters were examined. Sixty-one, 12, and 17% of cases were considered positive for expression of p53, MDM2 and bcl-2, respectively. p53 expression correlated with stage (p=0.0209), but not MDM2 and bcl-2 with any clinicopathologic parameters. In Cox's regression analysis, staging demonstrated a statistically worse prognosis (hazard ratio 1.636; p=0.0059) while bcl-2 (hazard ratio 0.179; p=0.0474) expression showed favorable prognosis in stage T2-4 invasive TCC of the bladder. Co-expression with p53/MDM2 (hazard ratio 0.367; p=0.0401) and p53/bcl-2 (hazard ratio 3.487; p=0.0111) overexpression were associated with favorable and unfavorable prognosis in stage T2-4 invasive TCC of the bladder, respectively. Our results indicate that staging is the most useful parameter to predict clinical outcome in patients with TCC of the bladder. Determinations of bcl-2 and co-expression p53/MDM2 and p53/bcl-2 may be useful for predicting tumor behavior and prognosis in stage T2-4 invasive type TCC of the bladder.

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March-April 2002
Volume 9 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Uchida T, Minei S, Gao J, Wang C, Satoh T and Baba S: Clinical significance of p53, MDM2 and bcl-2 expression in transitional cell carcinoma of the bladder. Oncol Rep 9: 253-259, 2002
APA
Uchida, T., Minei, S., Gao, J., Wang, C., Satoh, T., & Baba, S. (2002). Clinical significance of p53, MDM2 and bcl-2 expression in transitional cell carcinoma of the bladder. Oncology Reports, 9, 253-259. https://doi.org/10.3892/or.9.2.253
MLA
Uchida, T., Minei, S., Gao, J., Wang, C., Satoh, T., Baba, S."Clinical significance of p53, MDM2 and bcl-2 expression in transitional cell carcinoma of the bladder". Oncology Reports 9.2 (2002): 253-259.
Chicago
Uchida, T., Minei, S., Gao, J., Wang, C., Satoh, T., Baba, S."Clinical significance of p53, MDM2 and bcl-2 expression in transitional cell carcinoma of the bladder". Oncology Reports 9, no. 2 (2002): 253-259. https://doi.org/10.3892/or.9.2.253