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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March-April 2002 Volume 9 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer

  • Authors:
    • Yoichi Mizutani
    • Hiromi Wada
    • Osamu Yoshida
    • Masakazu Fukushima
    • Benjamin Bonavida
    • Akihiro Kawauchi
    • Tsuneharu Miki

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. ymizutan@koto.kpu-m.ac.jp
  • Pages: 289-292
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/or.9.2.289
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Abstract

There is no potent prognostic marker for recurrence in superficial bladder cancer at present. Thymidylate synthase (TS) is a key enzyme for pyrimidine synthesis. Dihydropyrimidine dehydrogenase (DPD) is an important pyrimidine salvage enzyme. We evaluated a combination of TS and DPD activities as a prognostic marker for recurrence in grade 1 and 2 superficial bladder cancer. The levels of TS and DPD activities in non-fixed fresh frozen bladder cancer specimens were determined biochemically by the 5-fluoro-2'-deoxyuridine 5'-monophosphate binding assay and the 5-fluorouracil degradation assay, respectively. Significantly, patients with low TS activity and high DPD activity had a longer post-operative tumor-free interval than those with either high TS activity or low DPD activity in the 2-year follow-up. There were no statistical differences observed in patient's sex and age as well as the histologic stage and grade of bladder cancer between the two groups. In addition, there is no correlation between TS and DPD activities. The present study suggests that a combination of TS and DPD activities may be an independent prognostic indicator for recurrence in grade 1 and 2 superficial bladder cancer, and that either high TS activity or low DPD activity predicts early recurrence.

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Copy and paste a formatted citation
Spandidos Publications style
Mizutani Y, Wada H, Yoshida O, Fukushima M, Bonavida B, Kawauchi A and Miki T: Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer. Oncol Rep 9: 289-292, 2002.
APA
Mizutani, Y., Wada, H., Yoshida, O., Fukushima, M., Bonavida, B., Kawauchi, A., & Miki, T. (2002). Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer. Oncology Reports, 9, 289-292. https://doi.org/10.3892/or.9.2.289
MLA
Mizutani, Y., Wada, H., Yoshida, O., Fukushima, M., Bonavida, B., Kawauchi, A., Miki, T."Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer". Oncology Reports 9.2 (2002): 289-292.
Chicago
Mizutani, Y., Wada, H., Yoshida, O., Fukushima, M., Bonavida, B., Kawauchi, A., Miki, T."Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer". Oncology Reports 9, no. 2 (2002): 289-292. https://doi.org/10.3892/or.9.2.289
Copy and paste a formatted citation
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Spandidos Publications style
Mizutani Y, Wada H, Yoshida O, Fukushima M, Bonavida B, Kawauchi A and Miki T: Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer. Oncol Rep 9: 289-292, 2002.
APA
Mizutani, Y., Wada, H., Yoshida, O., Fukushima, M., Bonavida, B., Kawauchi, A., & Miki, T. (2002). Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer. Oncology Reports, 9, 289-292. https://doi.org/10.3892/or.9.2.289
MLA
Mizutani, Y., Wada, H., Yoshida, O., Fukushima, M., Bonavida, B., Kawauchi, A., Miki, T."Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer". Oncology Reports 9.2 (2002): 289-292.
Chicago
Mizutani, Y., Wada, H., Yoshida, O., Fukushima, M., Bonavida, B., Kawauchi, A., Miki, T."Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer". Oncology Reports 9, no. 2 (2002): 289-292. https://doi.org/10.3892/or.9.2.289
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